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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Fosinopril Sodium | |
| Synonyms |
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| Definitions |
The sodium salt of fosinopril, a phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Fosinopril sodium is an ester prodrug that is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase of serum potassium. (NCI05) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C47542 |
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| CAS_Registry |
88889-14-9
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| CHEBI_ID |
CHEBI:5164
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| Chemical_Formula |
C30H45NO7P.Na
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| code |
C47542
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| Contributing_Source |
FDA
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| definition |
The sodium salt of fosinopril, a phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Fosinopril sodium is an ester prodrug that is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase of serum potassium. (NCI05)
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| FDA_UNII_Code |
NW2RTH6T2N
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Fosinopril Sodium
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| Legacy Concept Name |
Fosinopril_Sodium
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| Preferred_Name |
Fosinopril Sodium
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| prefixIRI |
NCIT:C47542
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| prefLabel |
Fosinopril Sodium
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0733440
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| subClassOf |
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