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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Ethosuximide | |
| Synonyms |
|
|
| Definitions |
A succinimide with anticonvulsant activity. The exact mechanism of action is not entirely understood, but most likely ethosuximide exerts its effects by partial antagonism of T-type calcium channels of the thalamic neurons. This leads to a decrease in burst firing of thalamocortical neurons, which stabilizes the nerve activity in the brain and prevents seizures. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C47523 |
|
| CAS_Registry |
77-67-8
|
|
| CHEBI_ID |
CHEBI:4887
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|
| Chemical_Formula |
C7H11NO2
|
|
| code |
C47523
|
|
| Contributing_Source |
FDA
|
|
| definition |
A succinimide with anticonvulsant activity. The exact mechanism of action is not entirely understood, but most likely ethosuximide exerts its effects by partial antagonism of T-type calcium channels of the thalamic neurons. This leads to a decrease in burst firing of thalamocortical neurons, which stabilizes the nerve activity in the brain and prevents seizures.
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|
| FDA_UNII_Code |
5SEH9X1D1D
|
|
| in_subset | ||
| label |
Ethosuximide
|
|
| Legacy Concept Name |
Ethosuximide
|
|
| NCI_Drug_Dictionary_ID |
694263
|
|
| NSC Number |
64013
|
|
| PDQ_Closed_Trial_Search_ID |
694263
|
|
| PDQ_Open_Trial_Search_ID |
694263
|
|
| Preferred_Name |
Ethosuximide
|
|
| prefixIRI |
NCIT:C47523
|
|
| prefLabel |
Ethosuximide
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0015043
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| subClassOf |
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