loading...| Preferred Name |
Mantle Cell Lymphoma |
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| Synonyms |
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| Definitions |
An aggressive, usually diffuse non-Hodgkin lymphoma composed of small to medium sized B-lymphocytes (centrocytes). Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C4337 |
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| ALT_DEFINITION |
An aggressive (fast-growing) type of B-cell non-Hodgkin lymphoma that usually occurs in middle-aged or older adults. It is marked by small- to medium-size cancer cells that may be in the lymph nodes, spleen, bone marrow, blood, and gastrointestinal system. |
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| code |
C4337 |
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| Contributing_Source |
Cellosaurus CPTAC CTEP CTRP GDC |
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| definition |
An aggressive, usually diffuse non-Hodgkin lymphoma composed of small to medium sized B-lymphocytes (centrocytes). Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA. |
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| Display_Name |
Mantle Cell Lymphoma |
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| ICD-O-3_Code |
9673/3 |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C168658 http://purl.obolibrary.org/obo/NCIT_C168656 http://purl.obolibrary.org/obo/NCIT_C168657 http://purl.obolibrary.org/obo/NCIT_C168655 http://purl.obolibrary.org/obo/NCIT_C158520 http://purl.obolibrary.org/obo/NCIT_C102905 http://purl.obolibrary.org/obo/NCIT_C168662 http://purl.obolibrary.org/obo/NCIT_C168661 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/ncit#oncotree_slim http://purl.obolibrary.org/obo/NCIT_C103133 http://purl.obolibrary.org/obo/NCIT_C156952 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C126659 http://purl.obolibrary.org/obo/NCIT_C165258 http://purl.obolibrary.org/obo/NCIT_C118168 |
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| Is_Value_For_GDC_Property | ||
| label |
Mantle Cell Lymphoma |
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| Legacy Concept Name |
Mantle_Cell_Lymphoma |
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| Maps_To |
Mantle cell lymphoma, lymph nodes of multiple sites Mantle cell lymphoma Mantle cell lymphoma (Includes all variants blastic, pleomorphic, small cell) Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse Mantle cell lymphoma, extranodal and solid organ sites Mantle cell lymphoma, unspecified site, extranodal and solid organ sites Mantle zone lymphoma Mantle cell lymphoma, unspecified site 9673/3 |
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| Neoplastic_Status |
Malignant |
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| Preferred_Name |
Mantle Cell Lymphoma |
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| prefixIRI |
NCIT:C4337 |
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| prefLabel |
Mantle Cell Lymphoma |
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| Semantic_Type |
Neoplastic Process |
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| UMLS_CUI |
C0334634 |
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| subClassOf |