Preferred Name

Cytarabine
Synonyms
Definitions

An antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. (NCI04)

ID

http://purl.obolibrary.org/obo/NCIT_C408

Accepted_Therapeutic_Use_For

Acute lymphocytic leukemia; Acute Nonlymphocytic leukemia; Bone marrow transplantation; Carcinomatous meningitis; Chronic myelogenous leukemia; Hogkins disease;

Meningeal leukemia; Acute Myeloid Leukemia; Meningitis lymphomatous; Myelodysplasic syndrome; Non-Hodgkins lymphoma; Ovarian cancer, intraperitoneal treatment; Retinoblastoma

ALT_DEFINITION

A drug used to treat certain types of leukemia and prevent the spread of leukemia to the meninges (three thin layers of tissue that cover and protect the brain and spinal cord). It is also being studied in the treatment of other types of cancer. Cytarabine blocks tumor growth by stopping DNA synthesis. It is a type of antimetabolite.

CAS_Registry

147-94-4

CHEBI_ID

CHEBI:28680

Chemical_Formula

C9H13N3O5

code

C408

Contributing_Source

CTRP

FDA

PCDC

definition

An antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. (NCI04)

Display_Name

Cytarabine

FDA_UNII_Code

04079A1RDZ

Has_Salt_Form

http://purl.obolibrary.org/obo/NCIT_C71603

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C186341

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C174019

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978

http://purl.obolibrary.org/obo/NCIT_C128784

http://purl.obolibrary.org/obo/NCIT_C186327

http://purl.obolibrary.org/obo/NCIT_C186328

http://purl.obolibrary.org/obo/NCIT_C157711

http://purl.obolibrary.org/obo/NCIT_C157712

http://purl.obolibrary.org/obo/NCIT_C173234

Is_PCDC_AML_Permissible_Value_For_Variable

http://purl.obolibrary.org/obo/NCIT_C274

Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C1909

label

Cytarabine

Legacy Concept Name

Cytosine_Arabinoside

Maps_To

Cytarabine

NCI_Drug_Dictionary_ID

39015

NSC Number

287459

PDQ_Closed_Trial_Search_ID

39015

PDQ_Open_Trial_Search_ID

39015

Preferred_Name

Cytarabine

prefixIRI

NCIT:C408

prefLabel

Cytarabine

Semantic_Type

Pharmacologic Substance

Nucleic Acid, Nucleoside, or Nucleotide

UMLS_CUI

C0010711

subClassOf

http://purl.obolibrary.org/obo/NCIT_C1557

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Mapping To Ontology Source
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C408 NCIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.065.300 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018383 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/OMIT_0004847 OMIT LOOM
http://stirdf.jst.go.jp/id/200907086890392751 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.685.245.453 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/MTHU059480 LOINC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039015 PDQ LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3565 OCHV LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387511003 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906077177645175 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-78080 SNMI LOOM
http://purl.bioontology.org/ontology/NDDF/002649 NDDF LOOM
http://purl.obolibrary.org/obo/CHEBI_28680 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_28680 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_28680 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_28680 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_28680 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_28680 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_28680 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_28680 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_28680 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28680 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_28680 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_28680 ECTO LOOM
http://purl.obolibrary.org/obo/CHEBI_28680 EFO LOOM
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http://purl.bioontology.org/ontology/RXNORM/3041 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003561 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP70367-5 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.742.680.245.453 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4018080 VANDF LOOM
http://purl.bioontology.org/ontology/MESH/D003561 MESH LOOM
http://www.co-ode.org/ontologies/galen#Cytarabine GALEN LOOM
https://go.drugbank.com/drugs/DB00987 MDM LOOM
http://purl.bioontology.org/ontology/ATC/L01BC01 ATC LOOM
http://www.drugbank.ca/drugs/DB00987 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0010711 OCHV LOOM
http://purl.bioontology.org/ontology/RCD/h31.. RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146419 NDFRT LOOM