Preferred Name

Triamterene

Synonyms
Definitions

A pteridine derivative with potassium-sparing diuretic property. Triamterene blocks the sodium-potassium exchange pump (Na-K-ATPase) in the luminal membrane of principal cells in the late distal tubule, cortical collecting tubule and collecting duct in the kidney. This reversible inhibition of the electrogenic sodium transport decreases the lumen-negative transepithelial potential difference and thus reduces the driving force for K+ movement into the tubular lumen resulting in the inhibition of sodium reabsorption in exchange for K+ and H+.

ID

http://purl.obolibrary.org/obo/NCIT_C29519

CAS_Registry

396-01-0

Chemical_Formula

C12H11N7

code

C29519

Contributing_Source

FDA

definition

A pteridine derivative with potassium-sparing diuretic property. Triamterene blocks the sodium-potassium exchange pump (Na-K-ATPase) in the luminal membrane of principal cells in the late distal tubule, cortical collecting tubule and collecting duct in the kidney. This reversible inhibition of the electrogenic sodium transport decreases the lumen-negative transepithelial potential difference and thus reduces the driving force for K+ movement into the tubular lumen resulting in the inhibition of sodium reabsorption in exchange for K+ and H+.

FDA_UNII_Code

WS821Z52LQ

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

label

Triamterene

Legacy Concept Name

Triamterene

NSC Number

639359

77625

Preferred_Name

Triamterene

prefixIRI

NCIT:C29519

prefLabel

Triamterene

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0040869

subClassOf

http://purl.obolibrary.org/obo/NCIT_C49186

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http://purl.obolibrary.org/obo/CHEBI_9671 CHEBI LOOM
http://www.drugbank.ca/drugs/DB00384 FTC LOOM
http://purl.bioontology.org/ontology/VANDF/4017902 VANDF LOOM
http://purl.obolibrary.org/obo/dinto_DB00384 DINTO LOOM
http://purl.obolibrary.org/obo/OMIT_0015062 OMIT LOOM
http://purl.bioontology.org/ontology/NDDF/002315 NDDF LOOM
http://purl.bioontology.org/ontology/RCD/b44.. RCD LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0040869 OCHV LOOM
http://www.gamuts.net/entity#triamterene GAMUTS LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146253 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.733.900 RH-MESH LOOM
http://purl.bioontology.org/ontology/ATC/C03DB02 ATC LOOM
https://go.drugbank.com/drugs/DB00384 MDM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12518 OCHV LOOM
http://www.co-ode.org/ontologies/galen#Triamterene GALEN LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29519 NCIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387053007 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/10763 RXNORM LOOM
http://stirdf.jst.go.jp/id/200907027300772906 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU001919 LOINC LOOM
http://bmi.utah.edu/ontologies/hfontology/C0040869 HFO LOOM
http://purl.bioontology.org/ontology/MESH/D014223 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014223 RH-MESH LOOM
http://purl.jp/bio/4/id/200906019949121355 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP14734-5 LOINC LOOM
http://purl.bioontology.org/ontology/SNMI/C-72430 SNMI LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017782 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/CHEBI_9671 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_9671 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_9671 DRON LOOM