Preferred Name |
Ramipril |
|
Synonyms |
|
|
Definitions |
A prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C29411 |
|
CAS_Registry |
87333-19-5 |
|
CHEBI_ID |
CHEBI:8774 |
|
Chemical_Formula |
C23H32N2O5 |
|
code |
C29411 |
|
Contributing_Source |
CTRP FDA |
|
definition |
A prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. |
|
Display_Name |
Ramipril |
|
FDA_UNII_Code |
L35JN3I7SJ |
|
Has_Target | ||
in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
label |
Ramipril |
|
Legacy Concept Name |
Ramipril |
|
NCI_Drug_Dictionary_ID |
686948 |
|
PDQ_Closed_Trial_Search_ID |
686948 |
|
PDQ_Open_Trial_Search_ID |
686948 |
|
Preferred_Name |
Ramipril |
|
prefixIRI |
NCIT:C29411 |
|
prefLabel |
Ramipril |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0072973 |
|
subClassOf |