loading...| Preferred Name |
Quinapril Hydrochloride |
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| Synonyms |
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| Definitions |
The hydrochloride salt form of quinapril, a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Quinapril is hydrolized into its active form quinaprilat, which binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. Quinapril also causes a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C29398 |
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| CAS_Registry |
82586-55-8 |
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| CHEBI_ID |
CHEBI:8714 |
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| Chemical_Formula |
C25H30N2O5.HCl |
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| code |
C29398 |
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| Contributing_Source |
FDA |
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| definition |
The hydrochloride salt form of quinapril, a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Quinapril is hydrolized into its active form quinaprilat, which binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. Quinapril also causes a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels. |
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| FDA_UNII_Code |
33067B3N2M |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Quinapril Hydrochloride |
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| Legacy Concept Name |
Quinapril |
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| Preferred_Name |
Quinapril Hydrochloride |
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| prefixIRI |
NCIT:C29398 |
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| prefLabel |
Quinapril Hydrochloride |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0770920 |
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| subClassOf |