loading...| Preferred Name | Benazepril Hydrochloride | |
| Synonyms |
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|
| Definitions |
The hydrochloride salt of benazepril, a carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, benazepril is metabolized to its active form benazeprilat. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C28862 |
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| CAS_Registry |
86541-74-4 |
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| Chemical_Formula |
C24H28N2O5.ClH |
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| code |
C28862 |
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| Contributing_Source |
CTRP FDA |
|
| definition |
The hydrochloride salt of benazepril, a carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, benazepril is metabolized to its active form benazeprilat. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. |
|
| Display_Name |
Benazepril Hydrochloride |
|
| FDA_UNII_Code |
N1SN99T69T |
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Benazepril Hydrochloride |
|
| Legacy Concept Name |
Benazepril_Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
686949 |
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| PDQ_Closed_Trial_Search_ID |
686949 |
|
| PDQ_Open_Trial_Search_ID |
686949 |
|
| Preferred_Name |
Benazepril Hydrochloride |
|
| prefixIRI |
NCIT:C28862 |
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| prefLabel |
Benazepril Hydrochloride |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0770917 |
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| subClassOf |