loading...| Preferred Name | Aminopterin | |
| Synonyms |
|
|
| Definitions |
A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C235 |
|
| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called antimetabolites. |
|
| CAS_Registry |
54-62-6 |
|
| CHEBI_ID |
CHEBI:22526 |
|
| Chemical_Formula |
C19H20N8O5 |
|
| code |
C235 |
|
| Contributing_Source |
FDA |
|
| definition |
A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04) |
|
| FDA_UNII_Code |
JYB41CTM2Q |
|
| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Aminopterin |
|
| Legacy Concept Name |
Aminopterin |
|
| Maps_To |
Aminopterin |
|
| NCI_Drug_Dictionary_ID |
39141 |
|
| NSC Number |
739 |
|
| PDQ_Closed_Trial_Search_ID |
39141 |
|
| PDQ_Open_Trial_Search_ID |
39141 |
|
| Preferred_Name |
Aminopterin |
|
| prefixIRI |
NCIT:C235 |
|
| prefLabel |
Aminopterin |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0002583 |
|
| subClassOf |