loading...| Preferred Name | Eflornithine | |
| Synonyms |
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|
| Definitions |
A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C226 |
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| Accepted_Therapeutic_Use_For |
Hirsutism, facial; Trypanosoma brucei gambiense (sleeping sickness) infection |
|
| ALT_DEFINITION |
A substance that is being studied in the prevention of cancer. It belongs to the family of drugs called antiprotozoals. |
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| CAS_Registry |
67037-37-0 70052-12-9 |
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| CHEBI_ID |
CHEBI:41948 |
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| Chemical_Formula |
C6H12F2N2O2 |
|
| code |
C226 |
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| Contributing_Source |
CTRP FDA |
|
| definition |
A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. (NCI04) |
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| Display_Name |
Eflornithine |
|
| FDA_UNII_Code |
ZQN1G5V6SR |
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| Has_Salt_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Eflornithine |
|
| Legacy Concept Name |
Eflornithine |
|
| Maps_To |
Eflornithine |
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| NCI_Drug_Dictionary_ID |
39754 |
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| PDQ_Closed_Trial_Search_ID |
39754 |
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| PDQ_Open_Trial_Search_ID |
39754 |
|
| Preferred_Name |
Eflornithine |
|
| prefixIRI |
NCIT:C226 |
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| prefLabel |
Eflornithine |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0002260 |
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| subClassOf |