loading...| Preferred Name |
Dulaglutide |
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| Synonyms |
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|
| Definitions |
A glucagon-like peptide-1 (GLP-1) receptor agonist that is 90% homologous to native human GLP-1 (7-37) and is composed of a dipeptidyl peptidase-IV-protected GLP-1 analog covalently linked to a human immunoglobulin G4 (IgG4)-Fc heavy chain, with antihyperglycemic activity. Upon administration, dulaglutide binds to and activates GLP-1 receptors, thereby increasing intracellular cyclic AMP (cAMP) in pancreatic beta cells. This increases glucose-dependent insulin release. Dulaglutide also reduces the elevated glucagon secretion by inhibiting alpha cells of the pancreas and slows gastric emptying. Altogether this lowers the postprandial glucose level. GLP-1 is normally secreted by L cells of the gastrointestinal (GI) mucosa in response to a meal to normalize blood glucose levels. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C169923 |
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| CAS_Registry |
923950-08-7 |
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| code |
C169923 |
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| Contributing_Source |
FDA |
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| definition |
A glucagon-like peptide-1 (GLP-1) receptor agonist that is 90% homologous to native human GLP-1 (7-37) and is composed of a dipeptidyl peptidase-IV-protected GLP-1 analog covalently linked to a human immunoglobulin G4 (IgG4)-Fc heavy chain, with antihyperglycemic activity. Upon administration, dulaglutide binds to and activates GLP-1 receptors, thereby increasing intracellular cyclic AMP (cAMP) in pancreatic beta cells. This increases glucose-dependent insulin release. Dulaglutide also reduces the elevated glucagon secretion by inhibiting alpha cells of the pancreas and slows gastric emptying. Altogether this lowers the postprandial glucose level. GLP-1 is normally secreted by L cells of the gastrointestinal (GI) mucosa in response to a meal to normalize blood glucose levels. |
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| FDA_UNII_Code |
WTT295HSY5 |
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| in_subset | ||
| label |
Dulaglutide |
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| NCI_META_CUI |
CL1382408 |
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| Preferred_Name |
Dulaglutide |
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| prefixIRI |
NCIT:C169923 |
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| prefLabel |
Dulaglutide |
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| Semantic_Type |
Pharmacologic Substance |
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| subClassOf |