Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

GLP-1 Mimetics
Synonyms
Definitions

Any of the analogues of the endogenous gastrointestinal hormone glucagon-like peptide-1 (GLP-1) with antihyperglycemic activity. GLP-1 mimetics mimic the activity of GLP-1 and thereby stimulate glucose-dependent secretion of insulin from pancreatic beta cells, suppress glucagon secretion from alpha cells, increase insulin sensitivity and inhibit gastric emptying thereby slowing absorption of nutrients and creating a satiating effect. Altogether, this lowers blood glucose levels. GLP-1 is rapidly inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4).
ID

http://purl.obolibrary.org/obo/NCIT_C98085
code

C98085
definition

Any of the analogues of the endogenous gastrointestinal hormone glucagon-like peptide-1 (GLP-1) with antihyperglycemic activity. GLP-1 mimetics mimic the activity of GLP-1 and thereby stimulate glucose-dependent secretion of insulin from pancreatic beta cells, suppress glucagon secretion from alpha cells, increase insulin sensitivity and inhibit gastric emptying thereby slowing absorption of nutrients and creating a satiating effect. Altogether, this lowers blood glucose levels. GLP-1 is rapidly inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4).
label

GLP-1 Mimetics
Preferred_Name

GLP-1 Mimetics
prefixIRI

NCIT:C98085
prefLabel

GLP-1 Mimetics
Semantic_Type

Chemical Viewed Functionally
UMLS_CUI

C3273809
subClassOf

http://purl.obolibrary.org/obo/NCIT_C29711
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