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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Dexverapamil | |
| Synonyms |
|
|
| Definitions |
The R-enantiomer of the calcium channel blocker verapamil. Dexverapamil competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. This agent exhibits decreased calcium antagonistic activity and toxicity compared to racemic verapamil. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1563 |
|
| CAS_Registry |
38321-02-7
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|
| Chemical_Formula |
C27H38N2O4
|
|
| code |
C1563
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|
| Contributing_Source |
FDA
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|
| definition |
The R-enantiomer of the calcium channel blocker verapamil. Dexverapamil competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. This agent exhibits decreased calcium antagonistic activity and toxicity compared to racemic verapamil. (NCI04)
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| FDA_UNII_Code |
QR5PYD126V
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|
| in_subset | ||
| label |
Dexverapamil
|
|
| Legacy Concept Name |
Dexverapamil
|
|
| NCI_Drug_Dictionary_ID |
41269
|
|
| PDQ_Closed_Trial_Search_ID |
41269
|
|
| PDQ_Open_Trial_Search_ID |
41269
|
|
| Preferred_Name |
Dexverapamil
|
|
| prefixIRI |
NCIT:C1563
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|
| prefLabel |
Dexverapamil
|
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
|
|
| UMLS_CUI |
C0280858
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| subClassOf |
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