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Biological and Environmental Research Ontology
| Preferred Name | Clarithromycin | |
| Synonyms |
|
|
| Definitions |
A semisynthetic 14-membered ring macrolide antibiotic. Clarithromycin binds to the 50S ribosomal subunit and inhibits RNA-dependent protein synthesis in susceptible organisms. Clarithromycin has been shown to eradicate gastric MALT (mucosa-associated lymphoid tissue) lymphomas, presumably due to the eradication of tumorigenic Helicobacter pylori infection. This agent also acts as a biological response modulator, possibly inhibiting angiogenesis and tumor growth through alterations in growth factor expression. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1054 |
|
| Accepted_Therapeutic_Use_For |
H. pylori infection; Various bacterial infections
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|
| ALT_DEFINITION |
An antibiotic drug used to treat infection. It belongs to the family of drugs called macrolides.
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| CAS_Registry |
81103-11-9
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|
| CHEBI_ID |
CHEBI:3732
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|
| Chemical_Formula |
C38H69NO13
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|
| code |
C1054
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|
| Contributing_Source |
CTRP FDA
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|
| definition |
A semisynthetic 14-membered ring macrolide antibiotic. Clarithromycin binds to the 50S ribosomal subunit and inhibits RNA-dependent protein synthesis in susceptible organisms. Clarithromycin has been shown to eradicate gastric MALT (mucosa-associated lymphoid tissue) lymphomas, presumably due to the eradication of tumorigenic Helicobacter pylori infection. This agent also acts as a biological response modulator, possibly inhibiting angiogenesis and tumor growth through alterations in growth factor expression. (NCI04)
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|
| Display_Name |
Clarithromycin
|
|
| FDA_UNII_Code |
H1250JIK0A
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|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Clarithromycin
|
|
| Legacy Concept Name |
Clarithromycin
|
|
| Maps_To |
Clarithromycin
|
|
| NCI_Drug_Dictionary_ID |
42308
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|
| NSC Number |
643733
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|
| PDQ_Closed_Trial_Search_ID |
42308
|
|
| PDQ_Open_Trial_Search_ID |
42308
|
|
| Preferred_Name |
Clarithromycin
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|
| prefixIRI |
NCIT:C1054
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|
| prefLabel |
Clarithromycin
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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|
| UMLS_CUI |
C0055856
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| subClassOf |
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