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G Protein-Coupled Receptor BioAssays Ontology
| Preferred Name | signal transduction | |
| Synonyms |
signaling cascade signalling cascade signaling pathway signalling pathway |
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| Definitions |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. |
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| ID |
http://purl.obolibrary.org/obo/GO_0007165 |
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| comment |
Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
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| database_cross_reference |
Reactome:REACT_114820 Reactome:REACT_12478 Reactome:REACT_100624 Reactome:REACT_93680 Reactome:REACT_115037 Reactome:REACT_114910 Reactome:REACT_98872 Reactome:REACT_113964 Reactome:REACT_89740 Reactome:REACT_102354 Reactome:REACT_114690 Reactome:REACT_114657 Reactome:REACT_78535 Reactome:REACT_113151 Wikipedia:Signal_transduction Reactome:REACT_31232 Reactome:REACT_115147 Reactome:REACT_112130 Reactome:REACT_113601 Reactome:REACT_112549
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| definition |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
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| has_alternative_id |
GO:0023033
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| has_narrow_synonym |
signaling cascade signalling cascade
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| has_obo_namespace |
biological_process
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| has_related_synonym |
signaling pathway signalling pathway
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| id |
GO:0007165
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| imported from | ||
| in_subset |
http://purl.obolibrary.org/obo/go#goslim_generic http://purl.obolibrary.org/obo/go#goslim_metagenomics http://purl.obolibrary.org/obo/go#goslim_candida http://purl.obolibrary.org/obo/go#goslim_plant |
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| label |
signal transduction
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| notation |
GO:0007165
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| prefixIRI |
GO:0007165
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| prefLabel |
signal transduction
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| subClassOf |
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