Antibiotic Resistance Ontology

Last uploaded: December 18, 2024
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Preferred Name

cilastatin
Synonyms
Definitions

Cilastatin is often prescribed with imipenem as a beta-lactam potentiator. Cilastatin inhibits enzymatic renal dehydropeptidase, which hydrolyzes imipenem, thereby preventing the metabolism of imipenem in vivo and maintaining longer antibiotic exposure and effect.
ID

http://purl.obolibrary.org/obo/ARO_3007063
database_cross_reference

ChEMBL:CHEMBL766

PubChem:6435415

CAS:82009-34-5

ChEBI:3697
definition

Cilastatin is often prescribed with imipenem as a beta-lactam potentiator. Cilastatin inhibits enzymatic renal dehydropeptidase, which hydrolyzes imipenem, thereby preventing the metabolism of imipenem in vivo and maintaining longer antibiotic exposure and effect.
has_obo_namespace

antibiotic_resistance
id

ARO:3007063
label

cilastatin
notation

ARO:3007063
prefLabel

cilastatin
subClassOf

http://purl.obolibrary.org/obo/ARO_3007226
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Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_3697 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3697 DRON LOOM
http://www.co-ode.org/ontologies/galen#Cilastatin GALEN LOOM
http://purl.bioontology.org/ontology/VANDF/4019679 VANDF LOOM
http://purl.jp/bio/4/id/200906078152979814 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP15813-6 LOINC LOOM
https://go.drugbank.com/drugs/DB01597 MDM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.392.368.533.200 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147771 NDFRT LOOM
http://purl.bioontology.org/ontology/MESH/D015377 MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_3697 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_3697 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_3697 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_3697 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3697 ECTO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016742 PMAPP-PMO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61679 NCIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D10.251.355.325.200 RH-MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0016146 OMIT LOOM
http://purl.obolibrary.org/obo/NCIT_C61679 BERO LOOM
http://stirdf.jst.go.jp/id/200907022624736412 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/2540 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015377 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-53752 SNMI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/96058005 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU018776 LOINC LOOM
http://www.drugbank.ca/drugs/DB01597 FTC LOOM
http://purl.obolibrary.org/obo/MESH_D015377 BERO LOOM
http://purl.obolibrary.org/obo/dinto_DB01597 DINTO LOOM