loading...| Preferred Name |
sulfonamide antibiotic |
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| Synonyms |
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| Definitions |
Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway. |
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| ID |
http://purl.obolibrary.org/obo/ARO_3000282 |
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| definition |
Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway. |
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| has_obo_namespace |
antibiotic_resistance |
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| id |
ARO:3000282 |
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| label |
sulfonamide antibiotic |
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| notation |
ARO:3000282 |
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| prefLabel |
sulfonamide antibiotic |
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| subClassOf |