loading...| Preferred Name |
Liraglutide |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassff8da8d5_9699_4253_9f02_2b88b5f0831f |
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| Chinese |
利拉鲁肽 |
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| label |
Liraglutide |
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| MESH_Definition |
An analog of GLUCAGON-LIKE PEPTIDE 1 and agonist of the GLUCAGON-LIKE PEPTIDE 1 RECEPTOR that is used as a HYPOGLYCEMIC AGENT and supplemental therapy in the treatment of DIABETES MELLITUS by patients who do not respond to METFORMIN. |
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| NCIt_Definition |
A long-acting, fatty acylated glucagon-like peptide-1 (GLP-1) analog administered subcutaneously, with antihyperglycemic activity. Liraglutide's prolonged action and half-life of 11-15 hours are attributed to the attachment of the fatty acid palmitic acid to GLP-1 that reversibly binds to albumin. Albumin binding protects liraglutide from immediate degradation and elimination and causes GLP-1 to be released from abumin in a slow and consistent manner. This agent may cause thyroid C-cell tumors and increases the risk of acute pancreatitis. |
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| prefLabel |
Liraglutide |
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| Synonyms |
N26-(Hexadecanoyl-gamma-glutamyle)-(34-arginine)glucagon-like-peptide-1-(7-37)-peptide NN-2211 Liraglutida Liraglutide (rDNA origin) Liraglutidum Liraglutide (genetical recombination) N²⁶-(N-Hexadecanoyl-L-gamma-glutamyl)-[34-L-arginine]glucagon-like peptide 1-(7-37)-peptide NN 2211 liraglutide N²⁶-(hexadecanoyl-gamma-glutamyle)-[34-arginine]GLP-1-(7-37)-peptide Liraglutide-containing product Victoza Liraglutide recombinant NN2211 Product containing liraglutide (medicinal product) 2211 NN Liraglutide (substance) Arg34Lys26-(N-ε-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37] 204656-20-2 |
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| subClassOf |