http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassf869b526_3723_439f_b451_ffa4f094d0ee

因妊娠期血药浓度易波动，建议癫痫孕妇每3个月根据AEDs血药浓度监测结果调整用药。 "关于成人癫痫患者长程管理的专家共识." 中华神经科杂志 .07(2013):496-499. 妊娠期生理变化可影响AEDs的代谢。因此，妊娠期需定期监测AEDs血药浓度，并结合临床发作情况及药物不良反应调整AEDs剂量，尽量控制癫痫发作。 "关于成人癫痫患者长程管理的专家共识." 中华神经科杂志 .07(2013):496-499.

药物浓度监测

Therapeutic drug monitoring

How should women taking AEDs be monitored to avoid worsening of seizures? For WWE taking AEDs, is dose escalation better than expectant management? 如何对WWE进行AEDs监测？计量递增（dose escalation）比预期管理（expectant management）更好吗？ [GRADES OF RECOMMENDATION:C] Based on current evidence, routine monitoring of serum AED levels in pregnancy is not recommended although individual circumstances may be taken into account. 【推荐等级：C】根据目前的证据，不建议常规监测妊娠期AEDs血清浓度。 https://www.rcog.org.uk/guidance/browse-all-guidance/green-top-guidelines/epilepsy-in-pregnancy-green-top-guideline-no-68/

Issues relating to AED blood level monitoring must be discussed with the patient. 与AEDs血药浓度监测相关的问题必须与患者讨论。 Scottish Intercollegiate Guidelines Network.Diagnosis and management of epilepsy in adults. SIGN 143. Edinburgh, SIGN, 2015. Available at: www.sign.ac.uk/guidelines/fulltext/143/index.html

For pregnant women with epilepsy, routine monitoring of AED concentrations is not indicated. However, the measurement of AED concentrations can be useful in the following circumstances: for adjustment of phenytoin dose, assessment of AED adherence and suspected AED toxicity. 对于妊娠期女性癫痫患者，不建议常规监测AEDs浓度，但在以下情况下，AEDs浓度的监测可能有用：调整PHT剂量、评估AEDs依从性、怀疑AEDs中毒。 Scottish Intercollegiate Guidelines Network.Diagnosis and management of epilepsy in adults. SIGN 143. Edinburgh, SIGN, 2015. Available at: www.sign.ac.uk/guidelines/fulltext/143/index.html

Monitoring, Drug Therapeutic Drug Monitoring Drug Monitoring, Therapeutic Monitoring, Therapeutic Drug

http://www.semanticweb.org//Childbearing-ageWomenwithEpilepsyOntology#OWLClass75df4782_cecd_4be4_8064_eacbabd91172