loading...| Preferred Name |
Mercaptopurine |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassd6044246_0373_4b08_a498_d02a7370447e |
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| Chinese |
巯嘌呤 |
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| label |
Mercaptopurine |
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| MESH_Definition |
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. |
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| NCIt_Definition |
A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis. (NCI04) |
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| prefLabel |
Mercaptopurine |
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| Synonyms |
Xaluprine MERCAPTOPURINE 24850 7-Mercapto-1346-tetrazaindene 6-thioxopurine 17-Dihydro-6H-purine-6-thione Bw 57-323H MERCAPTOPURINE A 06 Purine-6-thiol (8CI) 6 Thiohypoxanthine Azathiopurine Purine-6-thiol Monohydrate Purine 6-mercapto- 6 Thiopurine Purinethiol Mercaleukim WR-2785 MP Mercaleukin 6-Thiopurine Mercapto-6-purine Alti-Mercaptopurine U-4748 6-mercaptopurine monohydrate 755 6-mercaptopurine BW 57 323H Leukerin Ismipur Mern 6-Purinethiol Flocofil 6 MP 1226 Purimethol 6H-Purine-6-thione 17-dihydro- (9CI) 6H-Purine-6-thione 17-dihydro- Leupurin Product containing mercaptopurine (medicinal product) Purinethol 6MP Mercaptopurina 6-Thiohypoxanthine Mercaptopurine (substance) 6112-76-1 (monohydrate) Mercaptopurinum 50-44-2 6 Mercaptopurine 6-MP BW 57323H 17 dihydro-6H-purine-6-thione monohydrate Mercaptopurine-containing product Mercaptina Puri-Nethol Purixan 17-Dihydro-6H-purine-6-thione Monohydrate 6 Mercaptopurine Monohydrate Mercapurin 3H purine-6-thiol NCI-C04886 3H-Purine-6-thiol |
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