loading...| Preferred Name |
Megestrol acetate |
|
| Synonyms |
|
|
| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass31d10876_36ee_42b3_9e8d_8931e656e3c9 |
|
| Chinese |
甲地孕酮 |
|
| label |
Megestrol acetate |
|
| MESH_Definition |
Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. It also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia. (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995) |
|
| NCIt_Definition |
The acetate salt form of megestrol, a synthetic derivative of the naturally occurring female sex hormone progesterone with potential anti-estrogenic and antineoplastic activity. Mimicking the action of progesterone, megestrol acetate binds to and activates nuclear progesterone receptors in the reproductive system, and causes the ligand-receptor complex to be translocated to the nucleus where it binds to and promotes expression of target genes. This leads to an alteration in protein synthesis, which modulates cell growth of reproductive tissues. Due to the negative feedback mechanism seen with progesterone, megestrol also blocks luteinizing hormone (LH) release from the pituitary gland, thereby leading to an inhibition of ovulation and an alteration in the cervical mucus and endometrium. Furthermore, without stimulation of LH, estrogen release from the ovaries is stopped, hence impedes the growth of estrogen-sensitive tumor cells. |
|
| prefLabel |
Megestrol acetate |
|
| Synonyms |
Megestrol acetate (substance) 17 Alpha-acetoxy-6-methylpregna-46-diene-320-dione Niagestin 6-Dehydro-6-methyl-17alpha-acetoxyprogesterone 6-Methyl-17α-hydroxy-delta(sup 6)-progesterone acetate Maygace 6-Methyl-17alpha-acetoxypregna-46-diene-320-dione 6-Methyl-delta(sup 46)-pregnadien-17α-ol-320-dione acetate 17.alpha.-Acetoxy-6-methylpregna-46-diene-320-dione 6-Methyl-6-dehydro-17.alpha.-acetoxyprogesterone BDH-1298 17-Hydroxy-6-methylpregna-46-diene-320-dione Acetate 6-Methyl-delta(sup 6)-dehydro-17α-acetoxyprogesterone 17alpha-Hydroxy-6-methylpregna-46-diene-320-dione acetate Acetate Megestrol Megestrol acetate (9beta10alpha)-17-(Acetyloxy)-6-methylpregna-46-diene-320-dione 6-Methyl-17α-acetoxypregna-46-diene-320-dione 17-Hydroxy-6-methylpregna-46-diene-320-dione 17-acetate Megestrol Acetate 6-Methyl-6-dehydro-17alpha-acetoxyprogesterone Pallace 6-Dehydro-6-methyl-17α-acetoxyprogesterone BDH 1298 17alpha-Acetoxy-6-dehydro-6-methylprogesterone 6-Dehydro-6-methyl-17 alpha-acetoxyprogesterone Megestil Megostat 6-Methyl-delta-46-pregnadien-17 alpha-ol-320-dione Acetate 6-Methyl-delta(sup 46)-pregnadien-17alpha-ol-320-dione acetate megestrol acetate 17-Acetoxy-6-methylpregna-46-diene-320-dione 6-Dehydro-6-methyl-17.alpha.-acetoxyprogesterone 6-Methyl-6-dehydro-17α-acetoxyprogesterone 17α-Acetoxy-6-dehydro-6-methylprogesterone MEGESTROL ACETATE SC-10363 17α-Hydroxy-6-methylpregna-46-diene-320-dione acetate 6-Methyl-17alpha-hydroxy-delta(sup 6)-progesterone acetate 17-Hydroxy-6-methylpregna-46-diene-320-dione acetate 6-methyl-delta-46-pregnadien-17 alpha-ol-320-dione acetate Ovaban Pregna-46-diene-320-dione 17-(acetyloxy)-6-methyl- Megace Megestat 17-hydroxy-6-methylpregna-46-diene-320-dione acetate 6-Methyl-delta(sup 6)-dehydro-17alpha-acetoxyprogesterone MGA |
|
| subClassOf |