Medication

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药物治疗

Medication

Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.

A drug product that contains one or more active and/or inactive ingredients; it is intended to treat, prevent or alleviate the symptoms of disease. This term does not refer to the individual ingredients that make up the product.

Discuss with women and girls of childbearing potential (including young girls who are likely to need treatment into their childbearing years), and their parents and/or carers if appropriate, the risk of AEDs causing malformations and possible neurodevelopmental impairments in an unborn child. Assess the risks and benefits of treatment with individual drugs. There are limited data on risks to the unborn child associated with newer drugs. Specifically discuss the risk of continued use of sodium valproate to the unborn child, being aware that higher doses of sodium valproate (more than 800 mg/day) and polytherapy, particularly with sodium valproate, are associated with greater risk.[new2012] 请告知有生育潜力的女性患者（包括可能需要治疗至育龄期的年轻女孩）及她们的父母和/或照料人有关抗癫痫药物（AEDs）对胎儿的致畸和引起神经发育障碍的风险。并请评估使用特定药物治疗的风险与益处。目前新药对胎儿的风险数据较少。请特别讨论持续使用丙戊酸钠对未出生的孩子的风险，注意更高剂量的丙戊酸钠（超过 800 毫克/天）和综合疗法（特别是使用了丙戊酸钠时）可能与更大的风险有关。 nice.org.uk/guidance/cg137

Medication

What are the risks of congenital malformations in the fetus of pregnant women with epilepsy (WWE) exposed and not exposed to antiepileptic drugs (AEDs)? 宫内暴露于AEDs对胎儿先天畸形的影响 WWE who are planning their pregnancy should have a clinician competent in the management of epilepsy take responsibility for sharing decisions around choice and dose of AEDs, based on the risk to the fetus and control of seizures. 计划怀孕的WWE应由一位临床医生负责处理其癫痫发作、控制AEDs剂量。 [GRADES OF RECOMMENDATION:C] WWE should be reassured that most mothers have normal healthy babies and the risk of congenital malformations is low if they are not exposed to AEDs in the periconception period. 【推荐等级：C】应告知WWE，多数WWE母亲可拥有正常健康的婴儿，如果WWE在围妊娠期不接触AEDs，其后代发生先天畸形的风险很小。 [GRADES OF RECOMMENDATION:B] Women should be informed that the risk of congenital abnormalities in the fetus is dependent on the type, number and dose of AEDs. 【推荐等级：B】应告知WWE，胎儿先天畸形的风险取决于AEDs的类型、数量和剂量。 [GRADES OF RECOMMENDATION:B] The lowest effective dose of the most appropriate AED should be used. 【推荐等级：B】妊娠期WWE应选用适宜的最低有效剂量的AEDs。 Exposure to sodium valproate and other AED polytherapy should be minimised by changing the medication prior to conception, as recommended by an epilepsy specialist after a careful evaluation of the potential risks and benefits. Exposure to sodium valproate and other AED polytherapy should be minimised by changing the medication prior to conception, as recommended by an epilepsy specialist after a careful evaluation of the potential risks and benefits. 孕前使用VPA和其他AEDs综合治疗的患者，应根据癫痫专家的评估和建议下，在孕前即更换药物，以最大限度减少风险。 https://www.rcog.org.uk/guidance/browse-all-guidance/green-top-guidelines/epilepsy-in-pregnancy-green-top-guideline-no-68/

Medication Name Drug Drug or medicament Pharmaceutical Pharmaceuticals Preparation Pharmaceutical MEDS Products Pharmaceutical Pharmaceutical Preparation Pharmaceutic Preparations medication Drug Product Medication Medications Drug/agent PHARM PREPARATIONS Drugs Medicine Pharmaceutical Products Pharmaceutical Preparations Drug or medicament (substance) Medicines drug product Preparations Pharmaceutic Product Pharmaceutical Preparations Pharmaceutical PREPARATIONS PHARM Pharmaceutical / biologic product (product) drug/agent Pharmaceutical / biologic product Pharmaceutical Product

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