loading...| Preferred Name |
Azathioprine |
|
| Synonyms |
|
|
| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass08c66e6c_6d9c_454d_8c70_d128f0e040b1 |
|
| Chinese |
硫唑嘌呤 |
|
| label |
Azathioprine |
|
| MESH_Definition |
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed) |
|
| NCIt_Definition |
A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. |
|
| prefLabel |
Azathioprine |
|
| Synonyms |
6-(1-Methyl-4-nitro-5-imidazolyl)-mercaptopurine 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine AZTP Product containing azathioprine (medicinal product) 1H-Purine 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)- 6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine AZA Azathioprine-containing product Azathioprine 446-86-6 Azatioprina Azamun Azathioprine (substance) Azathioprinum Azothioprine 39084 |
|
| subClassOf |