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Toxic Process Ontology
Last uploaded:
December 6, 2022
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| Preferred Name | abacavir | |
| Synonyms |
{(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol abacavir ABC {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol Abacavir |
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| Definitions |
A 2,6-diaminopurine that is (1S)-cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_421707 |
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| database_cross_reference |
PMID:11806176 PMID:15887959 PMID:18029175 PMID:11678376 PMID:16458506 PMID:25017682 Drug_Central:34 PMID:16759112 PMID:12781181 PMID:26024233 PMID:17172311 PMID:25674793 PMID:24751900 PMID:17870541 PMID:16539393 PMID:18549801 Reaxys:7493116 Beilstein:7493116 CAS:136470-78-5 DrugBank:DB01048
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| definition |
A 2,6-diaminopurine that is (1S)-cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection.
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| has role |
http://purl.obolibrary.org/obo/CHEBI_53756 |
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| has_exact_synonym |
{(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol Abacavir
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| has_related_synonym |
{(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol abacavir ABC
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| id |
CHEBI:421707
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| label |
abacavir
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| notation |
CHEBI:421707
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| prefLabel |
abacavir
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| subClassOf |
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