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Sepsis Ontology
Last uploaded:
May 14, 2024
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| Preferred Name | Tirofiban | |
| Synonyms |
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| ID |
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Tirofiban |
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| definition |
A non-peptide tyrosine derivative, with anticoagulant activity. Upon administration, tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. This prevents the GP IIb/IIIa receptor complex-mediated activation of adenylyl cyclase. This results in decreased levels of cAMP, interferes with the platelet membrane function and subsequent platelet-platelet interaction, prevents the release of platelet granule constituents and prolongs bleeding time.
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| label |
Tirofiban
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| prefixIRI |
Tirofiban
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| prefLabel |
Tirofiban
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| reference | ||
| Synonyms |
TIROFIBAN
Tirofiban
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| subClassOf |
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Antiplatelet_Agent |
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