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Sepsis Ontology
Last uploaded:
May 14, 2024
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Preferred Name | Quinine | |
Synonyms |
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http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Quinine |
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definition |
A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.
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label |
Quinine
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prefixIRI |
Quinine
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prefLabel |
Quinine
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reference | ||
Synonyms |
(-)-Quinine
QUIN
QUININE
Quinine
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subClassOf |
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Antimalarial_Agent |
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