Sepsis Ontology

Last uploaded: May 14, 2024
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Preferred Name

Lepirudin
Synonyms
ID

http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Lepirudin
definition

A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and inactivates thrombin, producing dose-dependent increases in the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The mechanism of action of this agent is independent of antithrombin III and is not inhibited by platelet factor 4. Natural hirudin, a family of highly homologous isopolypeptides, is produced in trace amounts by the leech Hirudo medicinalis.
label

Lepirudin
prefixIRI

Lepirudin
prefLabel

Lepirudin
reference

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1839
Synonyms

Recombinant Hirudin LEPIRUDIN Lepirudin Refludan lepirudin
subClassOf

http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Direct_Thrombin_Inhibitor
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Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_142437 DRON LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000043356 PDQ LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#48816 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C083544 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_142437 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_142437 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_142437 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_142437 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_142437 DDSS LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025401 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/RXNORM/237057 RXNORM LOOM
http://purl.bioontology.org/ontology/NDDF/007520 NDDF LOOM
http://purl.bioontology.org/ontology/LNC/LP171615-0 LOINC LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02637 MIO LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02637 MIO LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02637 MIO LOOM
http://purl.bioontology.org/ontology/ATC/B01AE02 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0772394 OCHV LOOM
http://purl.bioontology.org/ontology/VANDF/4021096 VANDF LOOM
http://purl.obolibrary.org/obo/dinto_DB00001 DINTO LOOM
https://go.drugbank.com/drugs/DB00001 MDM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148552 NDFRT LOOM
http://purl.obolibrary.org/obo/NCIT_C1839 BERO LOOM
http://www.co-ode.org/ontologies/galen#Lepirudin GALEN LOOM
http://www.drugbank.ca/drugs/DB00001 FTC LOOM
http://purl.jp/bio/4/id/201306034051700490 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/C083544 MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1839 NCIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386955005 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RCD/brA.. RCD LOOM