loading...| Preferred Name |
Lamivudine |
|
| Synonyms |
|
|
| ID |
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Lamivudine |
|
| definition |
A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. |
|
| label |
Lamivudine |
|
| prefixIRI |
Lamivudine |
|
| prefLabel |
Lamivudine |
|
| reference | ||
| Synonyms |
2',3'-Dideoxy-3'-thiacytidine 4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone (-)-BCH-189 3'-Thia-2',3'-dideoxycytidine 3TC Epivir GR109714X LAM LAMIVUDINE Lamivudine lamivudine |
|
| subClassOf |