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Sepsis Ontology
Last uploaded:
May 14, 2024
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| Preferred Name | Lamivudine | |
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http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Lamivudine |
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| definition |
A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase.
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Lamivudine
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| prefixIRI |
Lamivudine
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Lamivudine
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| Synonyms |
2',3'-Dideoxy-3'-thiacytidine
4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
(-)-BCH-189
3'-Thia-2',3'-dideoxycytidine
3TC
Epivir
GR109714X
LAM
LAMIVUDINE
Lamivudine
lamivudine
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