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Sepsis Ontology
Last uploaded:
May 14, 2024
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| Preferred Name | Aztreonam | |
| Synonyms |
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| ID |
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Aztreonam |
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| definition |
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity. Aztreonam preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3), which is involved in bacterial cell wall synthesis, thereby inhibiting bacterial cell wall integrity and leading to cell lysis and death. This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms.
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| label |
Aztreonam
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| prefixIRI |
Aztreonam
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| prefLabel |
Aztreonam
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| reference | ||
| Synonyms |
AZTREONAM
Azactam
Aztreonam
SQ 26,776
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| subClassOf |
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Beta-Lactam_Antibiotic |
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