loading...| Preferred Name |
Argatroban |
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| Synonyms |
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| ID |
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Argatroban |
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| definition |
A synthetic derivative of L-arginine with antithrombotic activity. Argatroban is a univalent and direct inhibitor of fibrin-bound thrombin. This agent reversibly binds to the thrombin active site thereby preventing the thrombin-dependent reactions, which include conversion of fibrinogen to fibrin; the activation of factors V, VIII and XI; the activation of protein C; and platelet aggregation. Argatroban is highly selective for thrombin and is able to inhibit the action of both free and clot-associated thrombin. As a result, stabilization of blood clots and coagulation is inhibited. |
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| label |
Argatroban |
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| prefixIRI |
Argatroban |
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| prefLabel |
Argatroban |
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| reference | ||
| Synonyms |
1-[5-guanidino-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methyl-piperidine-2-carboxylic acid ARGATROBAN Argatroban Argipidine MD-805 |
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| subClassOf |
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Direct_Thrombin_Inhibitor |