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Radiation Oncology Ontology
Last uploaded:
June 19, 2018
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| Preferred Name | Erlotinib | |
| Synonyms |
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| Definitions |
A quinazoline derivative with antineoplastic properties. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic domain of epidermal growth factor receptor (EGFR) tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65530 |
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| definition |
A quinazoline derivative with antineoplastic properties. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic domain of epidermal growth factor receptor (EGFR) tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation.
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| isDefinedBy | ||
| label |
Erlotinib
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| prefixIRI |
ncit:C65530
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| prefLabel |
Erlotinib
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| seeAlso |
EuroCAT Umbrella Protocol for NSCLC
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| subClassOf |
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