PMO Precision Medicine Ontology

Last uploaded: December 16, 2020
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Preferred Name

I-kappaB Kinase/NF-kappaB Signaling
Synonyms
Definitions

"The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:jl, PMID:12773372, Reactome:R-HSA-209560]
ID

http://www.phoc.org.cn/pmo/class/PMO_00064233
Database_Cross_Reference

GO:0007249
Definition

"The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:jl, PMID:12773372, Reactome:R-HSA-209560]
Gene Annotation

NFKBIA(UniProtKB:P25963)

NLRC3(UniProtKB:Q7RTR2)

TIFA(UniProtKB:Q96CG3)

BCL3(UniProtKB:P20749)

BTK(UniProtKB:Q06187)

FAIM(UniProtKB:Q9NVQ4)

TLR9(UniProtKB:Q9NR96)

BIRC2(UniProtKB:Q13490)

RIPK3(UniProtKB:Q9Y572)

TANK(UniProtKB:Q92844)

AVPR2(UniProtKB:P30518)

TRADD(UniProtKB:Q15628)

AZI2(UniProtKB:Q9H6S1)

TLR7(UniProtKB:Q9NYK1)

SHARPIN(UniProtKB:Q9H0F6)

BIRC3(UniProtKB:Q13489)

RIPK1(UniProtKB:Q13546)

IRAK2(UniProtKB:O43187)

TRAF6(UniProtKB:Q9Y4K3)

NKIRAS1(UniProtKB:Q9NYS0)

UBA52(UniProtKB:P62987)

RELB(UniProtKB:Q01201)

IKBKB(UniProtKB:O14920)

HACD3(UniProtKB:Q9P035)

TAB3(UniProtKB:Q8N5C8)

CHUK(UniProtKB:O15111)

RNF31(UniProtKB:Q96EP0)

MAP3K14(UniProtKB:Q99558)

ROCK2(UniProtKB:O75116)

TNF(UniProtKB:P01375)

SNIP1(UniProtKB:Q8TAD8)

MAP3K7(UniProtKB:O43318)

TLR8(UniProtKB:Q9NR97)

IKBKG(UniProtKB:Q9Y6K9)

NFKBIL1(UniProtKB:Q9UBC1)

TAB2(UniProtKB:Q9NYJ8)

TBK1(UniProtKB:Q9UHD2)

LY96(UniProtKB:Q9Y6Y9)

RPS27A(UniProtKB:P62979)

IRAK1BP1(UniProtKB:Q5VVH5)

REL(UniProtKB:Q04864)

AKT1(UniProtKB:P31749)

TIAF1(UniProtKB:O95411)

TIFAB(UniProtKB:Q6ZNK6)

TICAM1(UniProtKB:Q8IUC6)

ZNF675(UniProtKB:Q8TD23)

RIPK2(UniProtKB:O43353)

BCL10(UniProtKB:O95999)

CARD9(UniProtKB:Q9H257)

TNFRSF1A(UniProtKB:P19438)

UBB(UniProtKB:P0CG47)

NKIRAS2(UniProtKB:Q9NYR9)

RBCK1(UniProtKB:Q9BYM8)

CD14(UniProtKB:P08571)

TRAF2(UniProtKB:Q12933)

TAB1(UniProtKB:Q15750)

ROCK1(UniProtKB:Q13464)

RELA(UniProtKB:Q04206)

H0Y858(UniProtKB:H0Y858)

TNIP2(UniProtKB:Q8NFZ5)

TLR3(UniProtKB:O15455)

CARD11(UniProtKB:Q9BXL7)

TICAM2(UniProtKB:Q86XR7)

TLR4(UniProtKB:O00206)

UBC(UniProtKB:P0CG48)
label

I-kappaB Kinase/NF-kappaB Signaling
MCID

MC04786214
PMOID

PMO:00064233
prefixIRI

pmo:PMO_00064233
prefLabel

I-kappaB Kinase/NF-kappaB Signaling
Synonym

"activation of the inhibitor of kappa kinase" RELATED []

"p50-dependent NF-kappaB signaling" RELATED [PMID:18292232]

"I-kappaB kinase/NF-kappaB signal transduction" EXACT [GOC:signaling]

"I-kappaB kinase/NF-kappaB cascade" RELATED [GOC:signaling]

"canonical NF-kappaB signaling cascade" EXACT [GOC:bf]

"NF-kappaB cascade" BROAD []
Tree Number

T10.1.26.1.33.23.39.9

T10.1.29.20.39.9
subClassOf

http://www.phoc.org.cn/pmo/class/PMO_00064230
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