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PMO Precision Medicine Ontology
| Preferred Name | SAGA Complex | |
| Synonyms |
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| Definitions |
"A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8." [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651] |
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| ID |
http://www.phoc.org.cn/pmo/class/PMO_00053296 |
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| Database_Cross_Reference |
GO:0000124
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| Definition |
"A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8." [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651]
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| Gene Annotation |
SUPT20HL1(UniProtKB:Q3ZLR7) F8VVB4(UniProtKB:F8VVB4) TAF12(UniProtKB:Q16514) TAF6L(UniProtKB:Q9Y6J9) TADA1(UniProtKB:Q96BN2) SUPT20H(UniProtKB:Q8NEM7) TRRAP(UniProtKB:Q9Y4A5) SUPT20HL2(UniProtKB:P0C7V6) SGF29(UniProtKB:Q96ES7) ATXN7L3(UniProtKB:Q14CW9) TAF9B(UniProtKB:Q9HBM6) TADA3(UniProtKB:O75528) USP22(UniProtKB:Q9UPT9) ENY2(UniProtKB:Q9NPA8) TAF6(UniProtKB:P49848) TAF9(UniProtKB:Q16594) F8VWA3(UniProtKB:F8VWA3)
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| label |
SAGA Complex
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| MCID |
MC04784830
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| PMOID |
PMO:00053296
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| prefixIRI |
pmo:PMO_00053296
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| prefLabel |
SAGA Complex
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| Synonym |
"Spt-Ada-Gcn5-acetyltransferase complex" EXACT []
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| Tree Number |
T10.3.14.13.7.126.25.2.5 T10.3.7.100.34.7.126.25.2.5 T10.3.9.325.71.43.2.1.2.5 T10.3.7.100.51.1.2.5 T10.3.9.325.3.3
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