Preferred Name

paromomycin
Synonyms

Hydroxymycin

paromomycine

paromomicina

Zygomycin A1

paromomycin

Paromomycin I

aminosidine

hydroxymycin

paromomycinum

Monomycin A

(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside

paucimycinum

crestomycin

Aminosidin

Catenulin

Neomycin E

R 400

R-400

estomycin

neomycin E

paucimycin

PAROMOMYCIN

Paromomycin

Definitions

An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.

ID

http://purl.obolibrary.org/obo/CHEBI_7934

bearer of

http://purl.obolibrary.org/obo/CHEBI_35820

http://purl.obolibrary.org/obo/CHEBI_36047

http://purl.obolibrary.org/obo/CHEBI_35443

charge

0

database_cross_reference

Drug_Central:2067

Patent:US2916485

PMID:18947845

KEGG:C00832

DrugBank:DB01421

CAS:7542-37-2

PMID:8036682

Patent:US2895876

KEGG:D07467

PDBeChem:PAR

PMID:18447603

Reaxys:72285

formula

C23H45N5O14

has role

http://purl.obolibrary.org/obo/CHEBI_35820

http://purl.obolibrary.org/obo/CHEBI_36047

http://purl.obolibrary.org/obo/CHEBI_35443

has_alternative_id

CHEBI:44703

has_exact_synonym

PAROMOMYCIN

Paromomycin

(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside

has_functional_parent

http://purl.obolibrary.org/obo/CHEBI_27955

has_obo_namespace

chebi_ontology

has_related_synonym

Hydroxymycin

paromomycine

paromomicina

Zygomycin A1

paromomycin

Paromomycin I

aminosidine

hydroxymycin

paromomycinum

Monomycin A

(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside

paucimycinum

crestomycin

Aminosidin

Catenulin

Neomycin E

R 400

R-400

estomycin

neomycin E

paucimycin

id

CHEBI:7934

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1

inchikey

UOZODPSAJZTQNH-LSWIJEOBSA-N

label

paromomycin

mass

615.62850

monoisotopicmass

615.29630

notation

CHEBI:7934

prefLabel

paromomycin

smiles

NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O

textual definition

An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.

subClassOf

http://purl.obolibrary.org/obo/CHEBI_22507

http://purl.obolibrary.org/obo/CHEBI_22479

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Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_7934 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7934 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7934 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7934 DINTO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7934 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7934 GO-PLUS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7934 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7934 DDSS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7934 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7934 UPHENO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7934 NIFSTD SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7934 FYPO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7934 GENEPIO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7934 MCO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7934 DRON LOOM
http://purl.obolibrary.org/obo/ARO_3000657 ARO LOOM
http://stirdf.jst.go.jp/id/200907052778016826 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4019878 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D09.408.051.623.635 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D010303 MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_7934 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_7934 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_7934 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_7934 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_7934 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_7934 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_7934 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_7934 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_7934 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_7934 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_7934 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_7934 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_7934 MCO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/38044001 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#9321 OCHV LOOM
https://go.drugbank.com/drugs/DB01421 MDM LOOM
http://purl.obolibrary.org/obo/ARO_3000657 ARO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D010303 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-56130 SNMI LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61878 NCIT LOOM
http://purl.obolibrary.org/obo/OMIT_0011299 OMIT LOOM
http://purl.obolibrary.org/obo/MESH_D010303 BERO LOOM
http://purl.bioontology.org/ontology/NDDF/004965 NDDF LOOM
http://purl.bioontology.org/ontology/LNC/MTHU034080 LOINC LOOM
http://purl.obolibrary.org/obo/NCIT_C61878 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147963 NDFRT LOOM
http://purl.jp/bio/4/id/200906081796276750 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0030576 OCHV LOOM
http://purl.bioontology.org/ontology/ATC/A07AA06 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/7934 RXNORM LOOM
http://purl.bioontology.org/ontology/LNC/LP66604-7 LOINC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00020964 PMAPP-PMO LOOM