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The Prescription of Drugs Ontology
| Preferred Name | Paromomycin | |
| Synonyms |
Hydroxymycin paromomycine paromomicina Zygomycin A1 paromomycin Paromomycin I aminosidine hydroxymycin paromomycinum Monomycin A (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside paucimycinum crestomycin Aminosidin Catenulin Neomycin E R 400 R-400 estomycin neomycin E paucimycin PAROMOMYCIN Paromomycin |
|
| Definitions |
An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_7934 |
|
| alternative term |
Hydroxymycin paromomycine paromomicina Zygomycin A1 paromomycin Paromomycin I aminosidine hydroxymycin paromomycinum Monomycin A (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside paucimycinum crestomycin Aminosidin Catenulin Neomycin E R 400 R-400 estomycin neomycin E paucimycin PAROMOMYCIN Paromomycin
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|
| bearer_of |
http://purl.obolibrary.org/obo/CHEBI_35820 http://purl.obolibrary.org/obo/CHEBI_36047 |
|
| charge |
0
|
|
| database_cross_reference |
Drug_Central:2067 Patent:US2916485 PMID:18947845 KEGG:C00832 DrugBank:DB01421 CAS:7542-37-2 PMID:8036682 Patent:US2895876 KEGG:D07467 PDBeChem:PAR PMID:18447603 Reaxys:72285
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|
| formula |
C23H45N5O14
|
|
| has functional parent | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_35820 http://purl.obolibrary.org/obo/CHEBI_36047 |
|
| has_alternative_id |
CHEBI:44703
|
|
| has_exact_synonym |
PAROMOMYCIN Paromomycin (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
|
|
| has_obo_namespace |
chebi_ontology
|
|
| has_related_synonym |
Hydroxymycin paromomycine paromomicina Zygomycin A1 paromomycin Paromomycin I aminosidine hydroxymycin paromomycinum Monomycin A (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside paucimycinum crestomycin Aminosidin Catenulin Neomycin E R 400 R-400 estomycin neomycin E paucimycin
|
|
| has_RxCUI |
7934
|
|
| id |
CHEBI:7934
|
|
| in_subset | ||
| inchi |
InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
|
|
| inchikey |
UOZODPSAJZTQNH-LSWIJEOBSA-N
|
|
| label |
paromomycin Paromomycin
|
|
| mass |
615.62850
|
|
| monoisotopicmass |
615.29630
|
|
| notation |
CHEBI:7934
|
|
| prefixIRI |
CHEBI:7934
|
|
| prefLabel |
Paromomycin
|
|
| smiles |
NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O
|
|
| textual definition |
An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
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