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The Prescription of Drugs Ontology
| Preferred Name | Procarbazine | |
| Synonyms |
2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide procarbazina procarbazinum 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide Procarbazin procarbazine 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide |
|
| Definitions |
A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_71417 |
|
| alternative term |
2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide procarbazina procarbazinum 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide Procarbazin procarbazine 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide
|
|
| bearer_of | ||
| charge |
0
|
|
| database_cross_reference |
PMID:21420247 Wikipedia:Procarbazine PMID:22708037 PMID:21870118 PMID:22913972 DrugBank:DB01168 PMID:22423248 HMDB:HMDB0015299 KEGG:C07402 Patent:US2007122414 Patent:US2008107661 PMID:21703849 CAS:671-16-9 KEGG:D08423 PMID:22851558 Patent:US3830840 Drug_Central:2272 PMID:21740300 Reaxys:958270 LINCS:LSM-2272 Patent:BE618638 PMID:23071237 Patent:US3520926 PMID:22744756
|
|
| formula |
C12H19N3O
|
|
| has role | ||
| has_alternative_id |
CHEBI:8432
|
|
| has_exact_synonym |
N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide
|
|
| has_obo_namespace |
chebi_ontology
|
|
| has_related_synonym |
2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide procarbazina procarbazinum 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide Procarbazin procarbazine 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine
|
|
| has_RxCUI |
8702
|
|
| id |
CHEBI:71417
|
|
| in_subset | ||
| inchi |
InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16)
|
|
| inchikey |
CPTBDICYNRMXFX-UHFFFAOYSA-N
|
|
| is conjugate base of | ||
| label |
procarbazine Procarbazine
|
|
| mass |
221.29880
|
|
| monoisotopicmass |
221.15281
|
|
| notation |
CHEBI:71417
|
|
| prefixIRI |
CHEBI:71417
|
|
| prefLabel |
Procarbazine
|
|
| smiles |
CNNCc1ccc(cc1)C(=O)NC(C)C
|
|
| textual definition |
A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
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|
| subClassOf |
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| No notes to display |