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The Prescription of Drugs Ontology
Last uploaded:
September 4, 2020
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| Preferred Name | axitinib | |
| Synonyms |
N-methyl-2-({3-[(E)-2-(pyridin-2-yl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide AG-013736 Inlyta axitinib axitinibum N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide |
|
| Definitions |
An indazole substituted at position 3 by a 2-(pyridin-2-yl)vinyl group and at position 6 by a 2-(N-methylaminocarboxy)phenylsulfanyl group. Used for the treatment of advanced renal cell carcinoma after failure of a first line systemic treatment. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_66910 |
|
| alternative term |
N-methyl-2-({3-[(E)-2-(pyridin-2-yl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide AG-013736 Inlyta axitinib axitinibum N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide
|
|
| bearer_of |
http://purl.obolibrary.org/obo/CHEBI_35610 |
|
| charge |
0
|
|
| database_cross_reference |
PMID:22699078 PMID:22248343 PMID:22168366 CAS:319460-85-0 Wikipedia:Axitinib Drug_Central:4225 Reaxys:11333336 PMID:22733795 PMID:20740300 PMID:22170007 PMID:22644797 PMID:22545314 PMID:22504156 PMID:21670972 PMID:22549112 PMID:22706540 PMID:21301929 KEGG:D03218 PMID:22683928 PMID:22787405
|
|
| formula |
C22H18N4OS
|
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_35610 |
|
| has_exact_synonym |
N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide
|
|
| has_obo_namespace |
chebi_ontology
|
|
| has_related_synonym |
N-methyl-2-({3-[(E)-2-(pyridin-2-yl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide AG-013736 Inlyta axitinib axitinibum
|
|
| has_RxCUI |
1242999
|
|
| id |
CHEBI:66910
|
|
| in_subset | ||
| inchi |
InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+
|
|
| inchikey |
RITAVMQDGBJQJZ-FMIVXFBMSA-N
|
|
| label |
axitinib
|
|
| mass |
386.47000
|
|
| monoisotopicmass |
386.12013
|
|
| notation |
CHEBI:66910
|
|
| prefixIRI |
CHEBI:66910
|
|
| prefLabel |
axitinib
|
|
| smiles |
CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1
|
|
| textual definition |
An indazole substituted at position 3 by a 2-(pyridin-2-yl)vinyl group and at position 6 by a 2-(N-methylaminocarboxy)phenylsulfanyl group. Used for the treatment of advanced renal cell carcinoma after failure of a first line systemic treatment.
|
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_22702 http://purl.obolibrary.org/obo/CHEBI_35683 |
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