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The Prescription of Drugs Ontology
| Preferred Name | Misoprostol | |
| Synonyms |
Methyl (+-)-11-alpha,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate misoprostolum (11-alpha,13E)-(+-)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester misoprostol (+-)-methyl (1R,2R,3R)-3-hydroxy-2-((E)-(4RS)-4-hydroxy-4-methyl-1-octenyl)-5-oxocyclopentaneheptanoate Arthrotec Cytotec |
|
| Definitions |
A diastereoisomeric mixture composed of approximately equal amounts of a double racemate of four of the sixteen possible diastereoisomers of methyl (13E)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate that is racemic prostaglandin E1 which is lacking the hydroxy group at position 15, but which has an additional hydroxy group at position 16. It is a synthetic prostaglandin E1 analogue, used in the treatment of gastric and duodenal ulcers. A weak abortifacient, it is also used for cervical ripening prior to surgical termination of pregnancy. The (11R,16S)-diastereoisomer is the pharmacologically active form. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_63610 |
|
| alternative term |
Methyl (+-)-11-alpha,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate misoprostolum (11-alpha,13E)-(+-)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester misoprostol (+-)-methyl (1R,2R,3R)-3-hydroxy-2-((E)-(4RS)-4-hydroxy-4-methyl-1-octenyl)-5-oxocyclopentaneheptanoate Arthrotec Cytotec
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|
| bearer_of |
http://purl.obolibrary.org/obo/CHEBI_49201 |
|
| database_cross_reference |
Patent:BE827127 CAS:59122-46-2 PMID:1417145 PMID:2109814 DrugBank:DB00929 KEGG:D00419 Patent:US3965143 PMID:3080288 PMID:11136959 Wikipedia:Misoprostol PMID:18690850 PMID:19740175 Reaxys:4155643 PMID:10945193 PMID:10949752
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|
| has part |
http://purl.obolibrary.org/obo/CHEBI_63700 http://purl.obolibrary.org/obo/CHEBI_63698 |
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_49201 |
|
| has_alternative_id |
CHEBI:6952
|
|
| has_obo_namespace |
chebi_ontology
|
|
| has_related_synonym |
Methyl (+-)-11-alpha,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate misoprostolum (11-alpha,13E)-(+-)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester misoprostol (+-)-methyl (1R,2R,3R)-3-hydroxy-2-((E)-(4RS)-4-hydroxy-4-methyl-1-octenyl)-5-oxocyclopentaneheptanoate Arthrotec Cytotec
|
|
| has_RxCUI |
42331
|
|
| id |
CHEBI:63610
|
|
| in_subset | ||
| label |
misoprostol Misoprostol
|
|
| notation |
CHEBI:63610
|
|
| overlaps |
http://purl.obolibrary.org/obo/CHEBI_63700 http://purl.obolibrary.org/obo/CHEBI_63698 |
|
| prefixIRI |
CHEBI:63610
|
|
| prefLabel |
Misoprostol
|
|
| textual definition |
A diastereoisomeric mixture composed of approximately equal amounts of a double racemate of four of the sixteen possible diastereoisomers of methyl (13E)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate that is racemic prostaglandin E1 which is lacking the hydroxy group at position 15, but which has an additional hydroxy group at position 16. It is a synthetic prostaglandin E1 analogue, used in the treatment of gastric and duodenal ulcers. A weak abortifacient, it is also used for cervical ripening prior to surgical termination of pregnancy. The (11R,16S)-diastereoisomer is the pharmacologically active form.
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| subClassOf |
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