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The Prescription of Drugs Ontology
| Preferred Name | Clofazimine | |
| Synonyms |
clofazimina clofazimine N,5-bis(4-chlorophenyl)-3-(isopropylimino)-3,5-dihydrophenazin-2-amine clofaziminum 3-(p-chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine (4-Chloro-phenyl)-[5-(4-chloro-phenyl)-3-isopropylimino-3,5-dihydro-phenazin-2-yl]-amine 3-(p-chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin N,5-bis(4-chlorophenyl)-3-(propan-2-ylimino)-3,5-dihydrophenazin-2-amine |
|
| Definitions |
3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_3749 |
|
| alternative term |
clofazimina clofazimine N,5-bis(4-chlorophenyl)-3-(isopropylimino)-3,5-dihydrophenazin-2-amine clofaziminum 3-(p-chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine (4-Chloro-phenyl)-[5-(4-chloro-phenyl)-3-isopropylimino-3,5-dihydro-phenazin-2-yl]-amine 3-(p-chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin N,5-bis(4-chlorophenyl)-3-(propan-2-ylimino)-3,5-dihydrophenazin-2-amine
|
|
| bearer_of |
http://purl.obolibrary.org/obo/CHEBI_35475 |
|
| charge |
0
|
|
| database_cross_reference |
Patent:US2948726 KEGG:D00278 PMID:17210775 DrugBank:DB00845 KEGG:C06915 Beilstein:8168151 PMID:3279207 LINCS:LSM-5669 CAS:2030-63-9
|
|
| formula |
C27H22Cl2N4
|
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_35475 |
|
| has_alternative_id |
CHEBI:355347
|
|
| has_exact_synonym |
N,5-bis(4-chlorophenyl)-3-(propan-2-ylimino)-3,5-dihydrophenazin-2-amine
|
|
| has_obo_namespace |
chebi_ontology
|
|
| has_related_synonym |
clofazimina clofazimine N,5-bis(4-chlorophenyl)-3-(isopropylimino)-3,5-dihydrophenazin-2-amine clofaziminum 3-(p-chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine (4-Chloro-phenyl)-[5-(4-chloro-phenyl)-3-isopropylimino-3,5-dihydro-phenazin-2-yl]-amine 3-(p-chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin
|
|
| has_RxCUI |
2592
|
|
| id |
CHEBI:3749
|
|
| in_subset | ||
| inchi |
InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3
|
|
| inchikey |
WDQPAMHFFCXSNU-UHFFFAOYSA-N
|
|
| label |
clofazimine Clofazimine
|
|
| mass |
473.39600
|
|
| monoisotopicmass |
472.12215
|
|
| notation |
CHEBI:3749
|
|
| prefixIRI |
CHEBI:3749
|
|
| prefLabel |
Clofazimine
|
|
| smiles |
CC(C)N=c1cc2n(-c3ccc(Cl)cc3)c3ccccc3nc2cc1Nc1ccc(Cl)cc1
|
|
| textual definition |
3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
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|
| subClassOf |
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