loading...| Preferred Name | Carbidopa | |
| Synonyms |
L-alpha-(3,4-dihydroxybenzyl)-alpha-hydrazinopropionic acid monohydrate carbidopa hydrate (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid monohydrate (S)-carbidopa hydrate (S)-(-)-carbidopa hydrate (-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate carbidopa monohydrate carbidopum monohydricum (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate (alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate carbidopa (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid--water (1/1) |
|
| Definitions |
The hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_3395 |
|
| alternative term |
L-alpha-(3,4-dihydroxybenzyl)-alpha-hydrazinopropionic acid monohydrate carbidopa hydrate (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid monohydrate (S)-carbidopa hydrate (S)-(-)-carbidopa hydrate (-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate carbidopa monohydrate carbidopum monohydricum (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate (alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate carbidopa (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid--water (1/1) |
|
| bearer_of |
http://purl.obolibrary.org/obo/CHEBI_48560 http://purl.obolibrary.org/obo/CHEBI_66956 |
|
| charge |
0 |
|
| database_cross_reference |
Patent:GB940596 Patent:DE2062332 KEGG:D00558 Patent:DE2062285 Patent:US3462536 PMID:10841799 CAS:38821-49-7 DrugBank:DB00190 |
|
| formula |
C10H16N2O5 |
|
| has part | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_48560 http://purl.obolibrary.org/obo/CHEBI_66956 |
|
| has_alternative_id |
CHEBI:212626 |
|
| has_exact_synonym |
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid--water (1/1) |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
L-alpha-(3,4-dihydroxybenzyl)-alpha-hydrazinopropionic acid monohydrate carbidopa hydrate (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid monohydrate (S)-carbidopa hydrate (S)-(-)-carbidopa hydrate (-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate carbidopa monohydrate carbidopum monohydricum (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate (alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate carbidopa |
|
| has_RxCUI |
2019 |
|
| id |
CHEBI:3395 |
|
| in_subset | ||
| inchi |
InChI=1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/m0./s1 |
|
| inchikey |
QTAOMKOIBXZKND-PPHPATTJSA-N |
|
| label |
carbidopa Carbidopa |
|
| mass |
244.24440 |
|
| monoisotopicmass |
244.10592 |
|
| notation |
CHEBI:3395 |
|
| overlaps | ||
| prefixIRI |
CHEBI:3395 |
|
| prefLabel |
Carbidopa |
|
| smiles |
O.C[C@@](Cc1ccc(O)c(O)c1)(NN)C(O)=O |
|
| textual definition |
The hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_35505 http://purl.obolibrary.org/obo/CHEBI_33566 |