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The Prescription of Drugs Ontology
Last uploaded:
September 4, 2020
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| Preferred Name | febuxostat | |
| Synonyms |
febuxostatum 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid Adenuric Donifoxate Febuday Feburic Goturic Goutex TEI 6720 TEI-6720 TMX 67 TMX-67 Uloric Zurig febuxostat 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid |
|
| Definitions |
A 1,3-thiazolemonocarboxylic acid that is 4-methyl-1,3-thiazole-5-carboxylic acid which is substituted by a 3-cyano-4-(2-methylpropoxy)phenyl group at position 2. It is an orally-active, potent, and selective xanthine oxidase inhibitor used for the treatment of chronic hyperuricaemia in patients with gout. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_31596 |
|
| alternative term |
febuxostatum 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid Adenuric Donifoxate Febuday Feburic Goturic Goutex TEI 6720 TEI-6720 TMX 67 TMX-67 Uloric Zurig febuxostat 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid
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|
| bearer_of | ||
| charge |
0
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|
| database_cross_reference |
PMID:31499267 PMID:31449565 PMID:31531831 Drug_Central:1137 LINCS:LSM-3064 PMID:31378626 PMID:30844048 Wikipedia:Febuxostat PMID:30919894 KEGG:D01206 DrugBank:DB04854 PMID:31332638 PDBeChem:TEI PMID:25724536 PMID:31267805 PMID:31447893 PMID:31560952 CAS:144060-53-7 PMID:31335677
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|
| formula |
C16H16N2O3S
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|
| has role | ||
| has_alternative_id |
CHEBI:45943
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|
| has_exact_synonym |
2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid
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|
| has_obo_namespace |
chebi_ontology
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|
| has_related_synonym |
febuxostatum 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid Adenuric Donifoxate Febuday Feburic Goturic Goutex TEI 6720 TEI-6720 TMX 67 TMX-67 Uloric Zurig febuxostat
|
|
| has_RxCUI |
73689
|
|
| id |
CHEBI:31596
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|
| in_subset | ||
| inchi |
InChI=1S/C16H16N2O3S/c1-9(2)8-21-13-5-4-11(6-12(13)7-17)15-18-10(3)14(22-15)16(19)20/h4-6,9H,8H2,1-3H3,(H,19,20)
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|
| inchikey |
BQSJTQLCZDPROO-UHFFFAOYSA-N
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|
| label |
febuxostat
|
|
| mass |
316.380
|
|
| monoisotopicmass |
316.08816
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|
| notation |
CHEBI:31596
|
|
| prefixIRI |
CHEBI:31596
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|
| prefLabel |
febuxostat
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|
| smiles |
C1(=CC(=C(C=C1)OCC(C)C)C#N)C2=NC(=C(S2)C(=O)O)C
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|
| textual definition |
A 1,3-thiazolemonocarboxylic acid that is 4-methyl-1,3-thiazole-5-carboxylic acid which is substituted by a 3-cyano-4-(2-methylpropoxy)phenyl group at position 2. It is an orally-active, potent, and selective xanthine oxidase inhibitor used for the treatment of chronic hyperuricaemia in patients with gout.
|
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_48652 |
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