Physician Data Query

Last uploaded: November 18, 2019
Preferred Name

azithromycin

Synonyms

CP 62993

Definitions

An azalide, derived from erythromycin, and a member of a subclass of macrolide antibiotics with bacteriocidal and bacteriostatic activities. Azithromycin reversibly binds to the 50S ribosomal subunit of the 70S ribosome of sensitive microorganisms, thereby inhibiting the translocation step of protein synthesis, wherein a newly synthesized peptidyl tRNA molecule moves from the acceptor site on the ribosome to the peptidyl (donor) site, and consequently inhibiting RNA-dependent protein synthesis leading to cell growth inhibition and cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28844" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28844" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000695416

altLabel

CP 62993

XZ-450

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[(3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentade

AzaSite

N-methyl-11-aza-10-deoxy-10-dihydroerythromycin A

Zithromax

CAS Registry

83905-01-5

cui

C0052796

C0678143

C0729049

C3536921

C1948900

DATE FIRST PUBLISHED

2011-02-11

Date last modified

2011-02-11

definition

An azalide, derived from erythromycin, and a member of a subclass of macrolide antibiotics with bacteriocidal and bacteriostatic activities. Azithromycin reversibly binds to the 50S ribosomal subunit of the 70S ribosome of sensitive microorganisms, thereby inhibiting the translocation step of protein synthesis, wherein a newly synthesized peptidyl tRNA molecule moves from the acceptor site on the ribosome to the peptidyl (donor) site, and consequently inhibiting RNA-dependent protein synthesis leading to cell growth inhibition and cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28844" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28844" NCI Thesaurus)

LT

TRD

NCI ID

C28844

notation

CDR0000695416

NSC Code

643732

ORIG STY

Drug/agent

prefLabel

azithromycin

tui

T109

T195

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