loading...| Preferred Name |
azithromycin |
|
| Synonyms |
Zithromax |
|
| Definitions |
An azalide, derived from erythromycin, and a member of a subclass of macrolide antibiotics with bacteriocidal and bacteriostatic activities. Azithromycin reversibly binds to the 50S ribosomal subunit of the 70S ribosome of sensitive microorganisms, thereby inhibiting the translocation step of protein synthesis, wherein a newly synthesized peptidyl tRNA molecule moves from the acceptor site on the ribosome to the peptidyl (donor) site, and consequently inhibiting RNA-dependent protein synthesis leading to cell growth inhibition and cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28844" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28844" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000695416 |
|
| altLabel |
Zithromax AzaSite XZ-450 N-methyl-11-aza-10-deoxy-10-dihydroerythromycin A CP 62993 (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[(3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentade |
|
| CAS Registry |
83905-01-5 |
|
| cui |
C0729049 C3536921 C0678143 C1948900 C0052796 |
|
| DATE FIRST PUBLISHED |
2011-02-11 |
|
| Date last modified |
2011-02-11 |
|
| definition |
An azalide, derived from erythromycin, and a member of a subclass of macrolide antibiotics with bacteriocidal and bacteriostatic activities. Azithromycin reversibly binds to the 50S ribosomal subunit of the 70S ribosome of sensitive microorganisms, thereby inhibiting the translocation step of protein synthesis, wherein a newly synthesized peptidyl tRNA molecule moves from the acceptor site on the ribosome to the peptidyl (donor) site, and consequently inhibiting RNA-dependent protein synthesis leading to cell growth inhibition and cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28844" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28844" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C28844 |
|
| notation |
CDR0000695416 |
|
| NSC Code |
643732 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
azithromycin |
|
| tui |
T109 T195 |