loading...| Preferred Name |
meclizine hydrochloride |
|
| Synonyms |
1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine dihydrochloride monohydrate |
|
| Definitions |
The hydrochloride salt form of meclizine, a synthetic piperazine with anti-emetic, sedative and histamine H1 antagonistic properties. Meclizine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. Meclizine hydrochloride may exert its antiemetic effects by its anticholinergic actions or due to a direct effect on the medullary chemoreceptive trigger zone. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29245" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29245" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000793974 |
|
| altLabel |
1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine dihydrochloride monohydrate meclizine HCl meclizine dihydrochloride monohydrate Antivert Bonine |
|
| CAS Registry |
31884-77-2 |
|
| cui |
C0305284 C0005985 C0282227 |
|
| DATE FIRST PUBLISHED |
2018-07-11 |
|
| Date last modified |
2018-07-20 |
|
| definition |
The hydrochloride salt form of meclizine, a synthetic piperazine with anti-emetic, sedative and histamine H1 antagonistic properties. Meclizine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. Meclizine hydrochloride may exert its antiemetic effects by its anticholinergic actions or due to a direct effect on the medullary chemoreceptive trigger zone. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29245" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29245" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C29245 |
|
| notation |
CDR0000793974 |
|
| NSC Code |
169189 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
meclizine hydrochloride |
|
| tui |
T109 T121 |