loading...| Preferred Name |
colistimethate sodium |
|
| Synonyms |
colistin sodium methanesulfonate |
|
| Definitions |
The sodium salt of colistimethate, a broad-spectrum polymyxin antibiotic against most aerobic Gram-negative bacteria except Proteus bacteria. Colistimethate sodium contains the pentasodium salt of the penta(methanesulfonic acid) derivative of colistin A as the major component and a small proportion of the petasodium salt of the pentamethanesulfonate derivative of colistin B. Colistins are cyclic polypeptides produced from Bacillus colistinus or B. polymyxa and function as a surfactant which penetrates into and disrupts the bacterial cell membrane, thereby resulting in bactericidal effect. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C65349" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C65349" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000788862 |
|
| altLabel |
colistin sodium methanesulfonate pentasodium colistinmethanesulfonate colimyscine W-1929 Coly-Mycin |
|
| CAS Registry |
8068-28-8 |
|
| cui |
C0110462 C2987579 C0701962 |
|
| DATE FIRST PUBLISHED |
2017-05-10 |
|
| Date last modified |
2017-05-10 |
|
| definition |
The sodium salt of colistimethate, a broad-spectrum polymyxin antibiotic against most aerobic Gram-negative bacteria except Proteus bacteria. Colistimethate sodium contains the pentasodium salt of the penta(methanesulfonic acid) derivative of colistin A as the major component and a small proportion of the petasodium salt of the pentamethanesulfonate derivative of colistin B. Colistins are cyclic polypeptides produced from Bacillus colistinus or B. polymyxa and function as a surfactant which penetrates into and disrupts the bacterial cell membrane, thereby resulting in bactericidal effect. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C65349" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C65349" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C65349 |
|
| notation |
CDR0000788862 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
colistimethate sodium |
|
| tui |
T195 T116 |