Physician Data Query

Last uploaded: August 27, 2019
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Preferred Name

aztreonam
Synonyms

SQ 26,776

Azactam
Definitions

A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity. Aztreonam preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3), which is involved in bacterial cell wall synthesis, thereby inhibiting bacterial cell wall integrity and leading to cell lysis and death. This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28845" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28845" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000788184
altLabel

SQ 26,776

Azactam
CAS Registry

78110-38-0
cui

C0004521

C0728974

C0699281
DATE FIRST PUBLISHED

2017-04-05
Date last modified

2017-04-05
definition

A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity. Aztreonam preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3), which is involved in bacterial cell wall synthesis, thereby inhibiting bacterial cell wall integrity and leading to cell lysis and death. This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28845" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28845" NCI Thesaurus)
LT

TRD
NCI ID

C28845
notation

CDR0000788184
NSC Code

646279
ORIG STY

Drug/agent
prefLabel

aztreonam
tui

T109

T195
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Mapping To Ontology Source
http://purl.bioontology.org/ontology/SNMI/C-53720 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-53720 SNMI CUI
http://purl.bioontology.org/ontology/RCD/x02Us RCD CUI
http://purl.bioontology.org/ontology/LNC/LP16041-3 LOINC CUI
http://purl.bioontology.org/ontology/RCD/e6f.. RCD CUI
http://purl.bioontology.org/ontology/SCTSPA/69918003 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000005876 NDFRT CUI
http://purl.bioontology.org/ontology/SCTSPA/387386004 SCTSPA CUI
http://purl.bioontology.org/ontology/MSHFRE/D001398 MSHFRE CUI
http://purl.bioontology.org/ontology/LNC/MTHU006798 LOINC CUI
http://purl.bioontology.org/ontology/MESH/D001398 MESH CUI
http://purl.bioontology.org/ontology/NDDF/002807 NDDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/69918003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146126 NDFRT CUI
http://purl.bioontology.org/ontology/ATC/J01DF01 ATC CUI
http://purl.bioontology.org/ontology/VANDF/4017762 VANDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387386004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/RXNORM/1272 RXNORM CUI
http://purl.bioontology.org/ontology/MSHFRE/D001398 MSHFRE CUI
http://purl.bioontology.org/ontology/MESH/D001398 MESH CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387386004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MESH/D001398 MESH CUI
http://purl.bioontology.org/ontology/RXNORM/202561 RXNORM CUI
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Aztreonam SEPON LOOM
http://purl.bioontology.org/ontology/SNMI/C-53720 SNMI LOOM
http://purl.bioontology.org/ontology/LNC/LP16041-3 LOINC LOOM
http://purl.bioontology.org/ontology/RCD/e6f.. RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.500.044 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015911 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#1644 OCHV LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28845 NCIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D001398 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 EUPATH LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 DOID LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 HHEAR LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 GENEPIO LOOM
http://stirdf.jst.go.jp/id/200907073895397870 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU006798 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.411.350.044 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D001398 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.500.044 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/002807 NDDF LOOM
http://www.co-ode.org/ontologies/galen#Aztreonam GALEN LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146126 NDFRT LOOM
http://purl.bioontology.org/ontology/ATC/J01DF01 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4017762 VANDF LOOM
http://purl.obolibrary.org/obo/MESH_D001398 BERO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387386004 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/OMIT_0002774 OMIT LOOM
http://purl.bioontology.org/ontology/RXNORM/1272 RXNORM LOOM
http://purl.obolibrary.org/obo/ARO_3000550 ARO LOOM
http://purl.jp/bio/4/id/200906057545028482 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.108.500.044 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0004521 OCHV LOOM
https://go.drugbank.com/drugs/DB00355 MDM LOOM
http://purl.obolibrary.org/obo/CHEBI_2960 NIFSTD LOOM
http://purl.obolibrary.org/obo/NCIT_C28845 BERO LOOM