Physician Data Query

Last uploaded: August 28, 2024
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Preferred Name

cefoxitin sodium
Synonyms

Mefoxin

Pacetin
Definitions

The sodium salt form of cefoxitin, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefoxitin sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28915" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28915" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000787118
altLabel

Mefoxin

Pacetin
CAS Registry

33564-30-6
cui

C4733542

C0700446

C0701380
DATE FIRST PUBLISHED

2017-02-23
Date last modified

2017-02-23
definition

The sodium salt form of cefoxitin, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefoxitin sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28915" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28915" NCI Thesaurus)
LT

TRD
NCI ID

C28915
notation

CDR0000787118
ORIG STY

Drug/agent
prefLabel

cefoxitin sodium
tui

T109

T195

T121
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Mapping To Ontology Source
http://purl.bioontology.org/ontology/NDFRT/N0000146315 NDFRT CUI
http://purl.bioontology.org/ontology/SNMI/C-C1DCE SNMI CUI
http://purl.bioontology.org/ontology/SCTSPA/84165004 SCTSPA CUI
http://purl.bioontology.org/ontology/SNMI/C-53741 SNMI CUI
http://purl.bioontology.org/ontology/SNOMEDCT/84165004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDDF/002722 NDDF CUI
http://purl.bioontology.org/ontology/MESH/D002440 MESH CUI
http://purl.bioontology.org/ontology/VANDF/4017965 VANDF CUI
http://purl.bioontology.org/ontology/MSHFRE/D002440 MSHFRE CUI
http://purl.bioontology.org/ontology/NDFRT/N0000179590 NDFRT CUI
http://purl.bioontology.org/ontology/RXNORM/203118 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/203791 RXNORM CUI
http://purl.bioontology.org/ontology/RCD/x02iX RCD CUI
http://purl.bioontology.org/ontology/MESH/D002440 MESH CUI
http://purl.obolibrary.org/obo/NCIT_C28915 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146315 NDFRT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28915 NCIT LOOM
http://purl.obolibrary.org/obo/CHEBI_3501 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3501 BERO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#44767 OCHV LOOM
http://purl.bioontology.org/ontology/SNMI/C-53741 SNMI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/84165004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDDF/002722 NDDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0700446 OCHV LOOM
http://purl.bioontology.org/ontology/VANDF/4017965 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/203118 RXNORM LOOM