Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

nicorandil

Synonyms
Definitions

A niacinamide derivative, a plasma membrane adenosine triphosphate (ATP)-sensitive potassium (K+) (KATP) channel activator and a nitric oxide (NO) donor, with vasodilatory, antihypertensive and potential cardio- and lung-protective activities. Upon administration, nicorandil binds to and opens KATP channels, which causes relaxation of vascular smooth muscles, stimulates vasodilatation, reduces vasoresistance, decreases blood pressure and protects the myocardium against ischemia. In addition, nicorandil exerts nitrate-like properties, through the stimulation of guanylate cyclase, the downregulation of Rho-kinase activity and the further promotion of venous vasodilation. Although the mechanism of action has not been fully elucidated, nicorandil may exhibit protective activity against radiation-induced lung and heart toxicity, possibly by preventing both accumulation of reactive oxygen species (ROS) and ROS-induced cellular damage. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C84012" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C84012" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000783858

CAS Registry

65141-46-0

cui

C0068700

DATE FIRST PUBLISHED

2016-09-26

Date last modified

2016-10-27

definition

A niacinamide derivative, a plasma membrane adenosine triphosphate (ATP)-sensitive potassium (K+) (KATP) channel activator and a nitric oxide (NO) donor, with vasodilatory, antihypertensive and potential cardio- and lung-protective activities. Upon administration, nicorandil binds to and opens KATP channels, which causes relaxation of vascular smooth muscles, stimulates vasodilatation, reduces vasoresistance, decreases blood pressure and protects the myocardium against ischemia. In addition, nicorandil exerts nitrate-like properties, through the stimulation of guanylate cyclase, the downregulation of Rho-kinase activity and the further promotion of venous vasodilation. Although the mechanism of action has not been fully elucidated, nicorandil may exhibit protective activity against radiation-induced lung and heart toxicity, possibly by preventing both accumulation of reactive oxygen species (ROS) and ROS-induced cellular damage. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C84012" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C84012" NCI Thesaurus)

NCI ID

C84012

notation

CDR0000783858

ORIG STY

Drug/agent

prefLabel

nicorandil

tui

T109

T121

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http://purl.bioontology.org/ontology/NDFRT/N0000167327 NDFRT CUI
http://purl.bioontology.org/ontology/SCTSPA/319304004 SCTSPA CUI
http://purl.bioontology.org/ontology/RXNORM/31748 RXNORM CUI
http://purl.bioontology.org/ontology/ATC/C01DX16 ATC CUI
http://purl.bioontology.org/ontology/RCD/blf.. RCD CUI
http://purl.bioontology.org/ontology/MSHFRE/D020108 MSHFRE CUI
http://purl.bioontology.org/ontology/MESH/D020108 MESH CUI
http://purl.bioontology.org/ontology/SCTSPA/395809002 SCTSPA CUI
http://purl.bioontology.org/ontology/SNOMEDCT/395809002 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/319304004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDDF/005831 NDDF CUI
http://purl.obolibrary.org/obo/CHEBI_31905 CHEBI LOOM
http://www.co-ode.org/ontologies/galen#Nicorandil GALEN LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84012 NCIT LOOM
http://purl.bioontology.org/ontology/RXNORM/31748 RXNORM LOOM
http://purl.bioontology.org/ontology/ATC/C01DX16 ATC LOOM
http://purl.obolibrary.org/obo/NCIT_C84012 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.066.515.530.498 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/blf.. RCD LOOM
http://purl.jp/bio/4/id/200906064306088585 IOBC LOOM
http://purl.obolibrary.org/obo/MESH_D020108 BERO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0068700 OCHV LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017194 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/CHEBI_31905 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_31905 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_31905 DRON LOOM
http://purl.bioontology.org/ontology/MESH/D020108 MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0020035 OMIT LOOM
http://stirdf.jst.go.jp/id/200907057502651589 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.583.575 RH-MESH LOOM
https://go.drugbank.com/drugs/DB09220 MDM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/395809002 SNOMEDCT LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02175 MIO LOOM
http://purl.bioontology.org/ontology/NDDF/005831 NDDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14493 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D020108 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.725.547.530.498 RH-MESH LOOM