Physician Data Query

Last uploaded: August 28, 2024
Preferred Name

zolmitriptan
Synonyms

Zomig

311C90

2-oxazolidinone, 4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-,(S)-

Definitions

A member of the triptan class agents with anti-migraine property. Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B expressed in intracranial arteries and 5_HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brain stem sensory nuclei. Receptor binding results in constriction of cranial vessels, reduction of the vessel pulsation and inhibition of nociceptive transmission, thereby providing relief of migraine headaches. Zolmitriptan may also relief migraine headaches by inhibition pro-inflammatory neuropeptide release. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47789" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47789" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000779011

altLabel

Zomig

311C90

2-oxazolidinone, 4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-,(S)-

CAS Registry

139264-17-8

cui

C0289361

C0528166

C0594405

DATE FIRST PUBLISHED

2016-02-24

Date last modified

2016-02-24

definition

A member of the triptan class agents with anti-migraine property. Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B expressed in intracranial arteries and 5_HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brain stem sensory nuclei. Receptor binding results in constriction of cranial vessels, reduction of the vessel pulsation and inhibition of nociceptive transmission, thereby providing relief of migraine headaches. Zolmitriptan may also relief migraine headaches by inhibition pro-inflammatory neuropeptide release. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47789" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47789" NCI Thesaurus)

LT

TRD

NCI ID

C47789

notation

CDR0000779011

ORIG STY

Drug/agent

prefLabel

zolmitriptan

tui

T109

T121

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Mapping To Ontology Source
http://purl.bioontology.org/ontology/MESH/C089750 MESH CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148550 NDFRT CUI
http://purl.bioontology.org/ontology/RXNORM/153354 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/135775 RXNORM CUI
http://purl.bioontology.org/ontology/RCD/dl8.. RCD CUI
http://purl.bioontology.org/ontology/NDDF/006460 NDDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/363582006 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SCTSPA/363582006 SCTSPA CUI
http://purl.bioontology.org/ontology/ATC/N02CC03 ATC CUI
http://purl.bioontology.org/ontology/MESH/C089750 MESH CUI
http://purl.bioontology.org/ontology/VANDF/4021094 VANDF CUI
http://purl.bioontology.org/ontology/SCTSPA/108406003 SCTSPA CUI
http://purl.bioontology.org/ontology/LNC/LP31829-2 LOINC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/108406003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/LNC/MTHU060550 LOINC CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006502 NDFRT CUI
http://purl.bioontology.org/ontology/MESH/C089750 MESH CUI
http://purl.bioontology.org/ontology/RCD/x03lT RCD CUI
http://purl.obolibrary.org/obo/CHEBI_10124 DRON LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148550 NDFRT LOOM
http://purl.bioontology.org/ontology/RXNORM/135775 RXNORM LOOM
http://purl.bioontology.org/ontology/RCD/dl8.. RCD LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026602 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0528166 OCHV LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47789 NCIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/363582006 SNOMEDCT LOOM
http://stirdf.jst.go.jp/id/200907059098148676 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/N02CC03 ATC LOOM
http://purl.bioontology.org/ontology/MESH/C089750 MESH LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148550 ODAE LOOM
http://www.drugbank.ca/drugs/DB00315 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#38438 OCHV LOOM
http://purl.obolibrary.org/obo/DRON_00014194 ODNAE LOOM
http://purl.bioontology.org/ontology/VANDF/4021094 VANDF LOOM
http://purl.jp/bio/4/id/200906071207856755 IOBC LOOM
http://purl.obolibrary.org/obo/NCIT_C47789 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C089750 RH-MESH LOOM
https://go.drugbank.com/drugs/DB00315 MDM LOOM
http://purl.bioontology.org/ontology/LNC/LP31829-2 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_10124 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_10124 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_10124 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_10124 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_10124 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_10124 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_10124 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_10124 NIFSTD LOOM
http://www.co-ode.org/ontologies/galen#Zolmitriptan GALEN LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060550 LOINC LOOM