loading...| Preferred Name |
dolutegravir |
|
| Synonyms |
2H-pyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazine-9-carboxamide, N-((2,4-difluorophenyl)methyl)-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)- GSK-1349572 Tivicay DTG GSK 1349572 |
|
| Definitions |
An orally bioavailable integrase strand transfer inhibitor (INSTI), with activity against human immunodeficiency virus type 1 (HIV-1) infection. Upon oral administration, dolutegravir binds to the active site of integrase, an HIV enzyme that catalyzes the transfer of viral genetic material into human chromosomes. This prevents integrase from binding to retroviral deoxyribonucleic acid (DNA), and blocks the strand transfer step, which is essential for the HIV replication cycle. This prevents HIV-1 replication. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C121543" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C121543" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000770209 |
|
| altLabel |
2H-pyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazine-9-carboxamide, N-((2,4-difluorophenyl)methyl)-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)- GSK-1349572 Tivicay DTG GSK 1349572 |
|
| CAS Registry |
1051375-16-6 |
|
| cui |
C3253985 C3542464 C3253986 |
|
| DATE FIRST PUBLISHED |
2015-03-18 |
|
| Date last modified |
2015-06-10 |
|
| definition |
An orally bioavailable integrase strand transfer inhibitor (INSTI), with activity against human immunodeficiency virus type 1 (HIV-1) infection. Upon oral administration, dolutegravir binds to the active site of integrase, an HIV enzyme that catalyzes the transfer of viral genetic material into human chromosomes. This prevents integrase from binding to retroviral deoxyribonucleic acid (DNA), and blocks the strand transfer step, which is essential for the HIV replication cycle. This prevents HIV-1 replication. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C121543" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C121543" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C121543 |
|
| notation |
CDR0000770209 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
dolutegravir |
|
| tui |
T109 T121 |