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Physician Data Query
| Preferred Name | paromomycin sulfate | |
| Synonyms |
humycin sulfate paramomycin sulfate Humatin aminosidine sulfate D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)-beta-D-ribofuranosyl-(1->5))-2-deoxy-, Sulfate(salt) |
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| Definitions |
The sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria. Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47652" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47652" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000769609 |
|
| altLabel |
humycin sulfate paramomycin sulfate Humatin aminosidine sulfate D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)-beta-D-ribofuranosyl-(1->5))-2-deoxy-, Sulfate(salt)
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| CAS Registry |
1263-89-4
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|
| cui |
C0733821 C0205881
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| DATE FIRST PUBLISHED |
2015-02-25
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| Date last modified |
2015-09-15
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|
| definition |
The sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria. Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47652" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47652" NCI Thesaurus)
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|
| LT |
TRD
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| NCI ID |
C47652
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|
| notation |
CDR0000769609
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|
| ORIG STY |
Drug/agent
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|
| prefLabel |
paromomycin sulfate
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|
| tui |
T109 T195
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